The Impact of Pediatric Marrow Transplantation on Late Pulmonary Function
- Determine the delayed effects of bone marrow transplantation preparative regimens on
pulmonary function in children surviving at least 5 years after transplantation for
- Determine the relationship between pulmonary function and growth rates in these
- Determine the effect of growth hormone treatment on pulmonary function in these
- Determine the relationship between pulmonary function and age at time of
transplantation in these patients.
- Determine the incidence and severity of restrictive pulmonary disease, and whether
these factors vary with increasing time after transplantation in these patients.
OUTLINE: Patients undergo respiratory history, signs and symptoms assessment, pulmonary
function tests (PFT) including spirometry, lung volumes, and diffusion, oxygen saturation by
pulse oximetry, and height measurement.
Patients are assessed at 5-10 years, 10-15 years, and over 15 years after bone marrow
transplantation. Patients with abnormal PFTs are assessed at more frequent intervals as
PROJECTED ACCRUAL: Approximately 280 patients will be accrued for this study.
Jean E. Sanders, MD
Fred Hutchinson Cancer Research Center
United States: Federal Government
|Fred Hutchinson Cancer Research Center||Seattle, Washington 98109|