Inclusion Criteria

Inclusion Criteria

Patients may be eligible for this study if they:

- Are at least 13 years old.

- Have the signed consent of parent/guardian if under 18 years of age.

- Are HIV-positive.

- Have failed 1 or 2 anti-HIV drug combination therapies which had at least 3 anti-HIV
drugs each.

- Have been on stable, triple anti-HIV drug therapy for at least 16 weeks prior to
study entry.

- Have a CD4 count under 300 cells/mm3 within 45 days prior to study entry.

- Agree not to become pregnant or make anyone else pregnant while on study drugs and
for 60 days after stopping drugs.

- Agree to use 2 methods of birth control while on study drugs and for 60 days after
stopping study drugs.

- Have a negative pregnancy test within 14 days prior to study entry.

Exclusion Criteria

Patients will not be eligible for this study if they:

- Received treatment for a serious infection or illness that was completed less than 2
weeks prior to study entry or, if they are still receiving treatment, he/she must
have been clinically stable for at least 14 days prior to study entry.

- Are pregnant or breast-feeding.

- Are using any drugs that affect the immune system, other than those specified by the
study.

- Received an immunization within 30 days prior to study entry.

- Have had pancreatitis.

- Have severe neuropathy (a condition affecting the nervous system).

- Received granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage
colony-stimulating factor (GM-CSF) within 14 days prior to study entry.

- Abuse alcohol or drugs.

- Have any medical condition that would make the patient unable to complete the study.

- Have used hydroxyurea within 24 weeks prior to study entry.

- Had hepatitis within 60 days of study entry.