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Analyses of Mutations Associated With Secondary Leukemia or Non-Hodgkin's Lymphoma in Patients Treated for Hodgkin's Disease or Childhood Brain Tumors


N/A
N/A
N/A
Not Enrolling
Both
Brain and Central Nervous System Tumors, Lymphoma

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Trial Information

Analyses of Mutations Associated With Secondary Leukemia or Non-Hodgkin's Lymphoma in Patients Treated for Hodgkin's Disease or Childhood Brain Tumors


OBJECTIVES: I. Determine the frequency of chromosome 3, 11, and 21 aberrations in peripheral
blood lymphocytes (PBL) specifically associated with acute myelogenous leukemia in patients
with adult or pediatric Hodgkin's disease treated with radiotherapy and/or chemotherapy. II.
Determine the frequency of these aberrations in patients with pediatric central nervous
system tumors treated with radiotherapy and/or chemotherapy. III. Determine the
glutathione-S-transferase allotype, associated with human toxicological response to
carcinogen exposure, for these patients. IV. Determine the frequency of t(14;18) gene
rearrangement, associated with deregulation of the bcl-2 proto-oncogene in non-Hodgkin's
lymphoma, in PBL of these patients.

OUTLINE: An extra tube of blood is collected before, every 4 weeks during, and every 3
months after radiotherapy and/or chemotherapy. DNA is isolated from the blood sample and the
GSTM1, GSTT1, and various cytochrome P (CYP) 450 genotypes are determined by polymerase
chain reaction (PCR). Mononuclear leukocytes are analyzed for chromosome aberrations on
chromosome numbers 3, 11, and 21. Pretreatment karyotype and frequency of translocations are
determined for each patient. Peripheral blood lymphocyte DNA is also examined for t(14;18)
gene rearrangements.

PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study within 2 years.

Inclusion Criteria


DISEASE CHARACTERISTICS: Diagnosis of Hodgkin's disease Adult or child OR Diagnosis of
primary central nervous system (CNS) malignancy 16 and under Medulloblastoma Ependymoma
Brain stem glioma Astrocytoma Primitive neuroectodermal tumor (PNET) Proposed therapy must
include external beam radiotherapy and/or chemotherapy

PATIENT CHARACTERISTICS: Age: See Disease Characteristics Any age Performance status: Not
specified Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not
specified Renal: Not specified

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease
Characteristics Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics
Surgery: Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Principal Investigator

Edward C. Halperin, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Duke Cancer Institute

Authority:

United States: Federal Government

Study ID:

CDR0000067681

NCT ID:

NCT00006342

Start Date:

January 1997

Completion Date:

January 2001

Related Keywords:

  • Brain and Central Nervous System Tumors
  • Lymphoma
  • stage I adult Hodgkin lymphoma
  • stage II adult Hodgkin lymphoma
  • stage III adult Hodgkin lymphoma
  • stage IV adult Hodgkin lymphoma
  • recurrent adult Hodgkin lymphoma
  • childhood infratentorial ependymoma
  • childhood low-grade cerebral astrocytoma
  • childhood supratentorial ependymoma
  • stage II childhood Hodgkin lymphoma
  • stage I childhood Hodgkin lymphoma
  • stage III childhood Hodgkin lymphoma
  • stage IV childhood Hodgkin lymphoma
  • recurrent/refractory childhood Hodgkin lymphoma
  • childhood high-grade cerebral astrocytoma
  • untreated childhood brain stem glioma
  • recurrent childhood brain stem glioma
  • untreated childhood supratentorial primitive neuroectodermal tumor
  • recurrent childhood supratentorial primitive neuroectodermal tumor
  • untreated childhood cerebellar astrocytoma
  • recurrent childhood cerebellar astrocytoma
  • recurrent childhood cerebral astrocytoma
  • untreated childhood medulloblastoma
  • recurrent childhood medulloblastoma
  • newly diagnosed childhood ependymoma
  • recurrent childhood ependymoma
  • Brain Neoplasms
  • Hodgkin Disease
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms

Name

Location
Duke Comprehensive Cancer Center Durham, North Carolina  27710