Chemotherapy Intra-Arterial Hepatic With Oxaliplatin Combined With Leucovorin Calcium and Fluorouracil IV
OBJECTIVES: I. Determine the efficacy and tolerance of oxaliplatin by hepatic perfusion
combined with intravenous leucovorin calcium and fluorouracil in patients with liver
metastases from colorectal cancer.
OUTLINE: Patients receive oxaliplatin by hepatic perfusion over 2 hours on day 1 plus
leucovorin calcium IV over 2 hours and fluorouracil IV over 22 hours on days 1 and 2.
Treatment repeats every 14 days in the absence of disease progression or unacceptable
toxicity. If a good response is achieved after 8 courses of chemotherapy, patients may
undergo surgical resection of metastases.
PROJECTED ACCRUAL: A total of 20-40 patients will be accrued for this study.
Primary Purpose: Treatment
Michel Ducreux, MD, PhD
Gustave Roussy, Cancer Campus, Grand Paris
United States: Federal Government