Phase II Treatment of Adults With Brain Metastases With Temodar
- Determine the activity of temozolomide in patients with brain metastases.
- Determine the toxicity of this treatment in these patients.
OUTLINE: Patients are stratified according to type of primary cancer (lung carcinoma vs
breast carcinoma vs malignant melanoma vs renal cell carcinoma vs colorectal carcinoma vs
Patients receive oral temozolomide daily on days 1-7 and 15-21. Treatment repeats every 28
days for up to 12 courses in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 180 patients (30 per stratum) will be accrued for this study.
Primary Purpose: Treatment
Henry S. Friedman, MD
United States: Federal Government
|Duke Comprehensive Cancer Center||Durham, North Carolina 27710|