Perfusion Magnetic Resonance Imaging of Brain Tumors: Correlation With Indicators of Angiogenesis
18 Years
N/A
Both
Brain and Central Nervous System Tumors
Trial Information
Perfusion Magnetic Resonance Imaging of Brain Tumors: Correlation With Indicators of Angiogenesis
OBJECTIVES: I. Correlate the findings of perfusion magnetic resonance imaging with known
tissue and serum markers of angiogenesis in patients with newly diagnosed surgically
resectable brain tumors.
OUTLINE: Patients undergo perfusion magnetic resonance imaging (MRI) scanning with contrast
in conjunction with preoperative conventional MRI scanning with contrast. Patients receive
gadopentetate dimeglumine IV over 5 seconds prior to perfusion MRI. Gadopentetate
dimeglumine is administered at a slower rate prior to conventional MRI. Patients undergo
blood draw to determine urokinase type plasminogen activator levels. After completion of
perfusion and conventional MRI scanning, brain tumor tissue samples are obtained during
surgical resection to determine tumor grade and type and urokinase type plasminogen
activator and basic fibroblast growth factor levels. If CSF removal is required during
surgery, then CSF samples are collected to determine urokinase type plasminogen activator
and basic fibroblast growth factor levels.
PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS: Newly diagnosed surgically resectable brain tumor
PATIENT CHARACTERISTICS: Age: Over 18 Performance status: Not specified Life expectancy:
Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified
Other: Able to tolerate gadopentetate dimeglumine contrast Medically stable
PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior
chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery:
See Disease Characteristics
Type of Study:
Interventional
Study Design:
Primary Purpose: Diagnostic
Principal Investigator
Hunt H. Batjer, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Robert H. Lurie Cancer Center
Authority:
United States: Federal Government
Study ID:
NU 95C1
NCT ID:
NCT00005790
Start Date:
April 1996
Completion Date:
May 1999
Related Keywords:
- Brain and Central Nervous System Tumors
- adult brain stem glioma
- adult ependymoma
- adult craniopharyngioma
- adult medulloblastoma
- adult meningioma
- adult glioblastoma
- adult oligodendroglioma
- adult anaplastic astrocytoma
- adult myxopapillary ependymoma
- adult anaplastic ependymoma
- adult anaplastic oligodendroglioma
- adult mixed glioma
- adult pineal parenchymal tumor
- adult central nervous system germ cell tumor
- adult pilocytic astrocytoma
- adult subependymoma
- adult diffuse astrocytoma
- adult ependymoblastoma
- adult pineocytoma
- adult pineoblastoma
- adult meningeal hemangiopericytoma
- adult choroid plexus tumor
- adult grade III meningioma
- adult giant cell glioblastoma
- adult gliosarcoma
- Brain Neoplasms
- Nervous System Neoplasms
- Central Nervous System Neoplasms
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