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Defining Functional Tissue in Brain Tumors With Integrated Neuroimaging (Pilot Study)

Phase 2
18 Years
55 Years
Not Enrolling
Brain and Central Nervous System Tumors

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Trial Information

Defining Functional Tissue in Brain Tumors With Integrated Neuroimaging (Pilot Study)

OBJECTIVES: I. Determine the definable topospecific relationship between functional
neuroactivation measured by functional magnetic resonance imaging (fMRI) and chemostructural
tissue measurements made with 1H-nuclear magnetic resonance spectroscopic imaging (1H-NMRSI)
in patients with newly diagnosed brain tumors situated in the vicinity of the brain's
language and motor regions. II. Determine if clinical improvement correlates with stronger
imaging signatures of neuroactivation on fMRI in this patient population. III. Determine if
functional loss during tumor recurrence or progression correlates with increases in choline
and decreases in N-acetylaspartate on 1H-NMRSI in regions that previously displayed
activation on fMRI or in associated underlying white matter regions in these patients.

OUTLINE: Patients undergo preoperative functional magnetic resonance imaging (fMRI),
1H-nuclear magnetic resonance spectroscopic imaging (1H-NMRSI), and conventional contrast
MRI over 2 hours followed by neurofunctional motor and/or language neurofunctional testing.
Intraoperatively, patients undergo corticography consisting of awake language mapping and
motor cortex stimulation. Patients undergo repeat imaging and neurofunctional evaluation at
2 weeks following surgery and prior to any radiotherapy or chemotherapy. Patients also
undergo neurological and neuropsychological testing consisting of basic gait, motor
coordination, reflexes, hand motor, tongue motor, and language evaluation to measure
baseline, preoperative, and postoperative clinical status and outcomes. Patients are
followed every 4 months for 1 year.

PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study over 4 years.

Inclusion Criteria

DISEASE CHARACTERISTICS: Newly diagnosed brain tumor Neuroradiological and clinical
evidence of probable glioma Lesion in close proximity to language and motor areas No prior

PATIENT CHARACTERISTICS: Age: 18 to 55 Performance status: Not specified Life expectancy:
Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified
Other: No other medical or psychiatric disorder No contraindications to MRI scanning
(e.g., metal implants, dental prostheses other than fillings, contrast allergies)

PRIOR CONCURRENT THERAPY: See Disease Characteristics

Type of Study:


Study Design:

Primary Purpose: Diagnostic

Principal Investigator

Jeffry Alger, PhD

Investigator Role:

Study Chair

Investigator Affiliation:

Jonsson Comprehensive Cancer Center


United States: Federal Government

Study ID:




Start Date:

March 1998

Completion Date:

Related Keywords:

  • Brain and Central Nervous System Tumors
  • adult glioblastoma
  • adult anaplastic astrocytoma
  • adult myxopapillary ependymoma
  • adult anaplastic ependymoma
  • adult anaplastic oligodendroglioma
  • adult mixed glioma
  • adult pilocytic astrocytoma
  • adult subependymoma
  • adult ependymoblastoma
  • adult oligodendroglioma
  • adult giant cell glioblastoma
  • adult gliosarcoma
  • Brain Neoplasms
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms