A Phase II Trial of Progressive Resistance Training (PRT) Plus Procrit for the Treatment of Anemia-Related Fatigue in Cancer Patients
OBJECTIVES: I. Determine the effect of progressive resistance training and epoetin alfa on
lean body mass, fatigue, exercise tolerance, functional capacity, and total body weight in
cancer patients with anemia related fatigue.
OUTLINE: Patients undergo progressive resistance training (PRT) consisting of 3 sets of 8
repetitions of concentric (lifting) and eccentric (lowering) exercises over 4-6 seconds each
using bench press, arm pull, knee extension, knee flexion, and double leg press followed by
1-2 minutes of rest between sets. Patients undergo warm up and cool down periods over 10
minutes prior to and following PRT. Patients perform PRT 3 times a week for 12 weeks.
Patients also receive epoetin alfa subcutaneously once weekly over 4-12 weeks in the absence
of unacceptable toxicity.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study over 15 months.
Primary Purpose: Supportive Care
Jamie Hayden Von Roenn, MD
Robert H. Lurie Cancer Center
United States: Food and Drug Administration
|Robert H. Lurie Comprehensive Cancer Center, Northwestern University||Chicago, Illinois 60611|