Phase 2
N/A
N/A
N/A
N/A
Open (Enrolling)
Both
Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Mixed Gliomas, Glioblastoma Multiforme, Recurrent Brain Tumor
Both
Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Mixed Gliomas, Glioblastoma Multiforme, Recurrent Brain Tumor
Trial Information
PROTOCOL OUTLINE:
Patients receive mercaptopurine IV on days 1-3, carmustine by continuous infusion on days
3-5, and streptozocin IV over 20 minutes on days 2-5. Patients receive treatment every 42
days, for up to 4 courses.
Inclusion Criteria
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics-- Histologically proven refractory or recurrent brain neoplasms
Glioblastoma multiforme Anaplastic astrocytoma Gliosarcoma Anaplastic oligodendroglioma
Mixed anaplastic glioma Unequivocally progressive primary brainstem tumors following
primary therapy Measurable disease --Prior/Concurrent Therapy-- Biologic therapy: Not
specified Chemotherapy: At least 4 weeks since prior chemotherapy At least 6 weeks since
prior nitrosoureas or mitomycin Endocrine therapy: Not specified Radiotherapy: Prior
radiotherapy allowed Surgery: Prior surgery allowed --Patient Characteristics-- Age: Not
specified Performance status: ECOG 0-2 Karnofsky 60-100% Hematopoietic: Granulocyte count
at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than
2.0 mg/dL SGOT no greater than 4 times normal Renal: Creatinine no greater than 2.0 mg/dL
Pulmonary: FEV1 greater than 1 L if symptomatic pulmonary disease present Other: No other
concurrent malignancies Not pregnant or lactating Negative pregnancy test Fertile patients
must use effective contraception
Type of Study:
Interventional
Study Design:
Primary Purpose: Treatment
Principal Investigator
Mark R. Gilbert
Investigator Role:
Study Chair
Investigator Affiliation:
Emory University
Authority:
United States: Federal Government
Study ID:
199/13310
NCT ID:
NCT00004688
Start Date:
August 1996
Completion Date:
Related Keywords:
- Anaplastic Astrocytoma
- Anaplastic Oligodendroglioma
- Mixed Gliomas
- Glioblastoma Multiforme
- Recurrent Brain Tumor
- adult anaplastic astrocytoma
- adult anaplastic oligodendroglioma
- adult brain stem glioma
- adult brain tumor
- adult glioblastoma multiforme
- adult infiltrating astrocytoma
- brain tumor
- genetic condition
- miscellaneous sites/terms
- mixed gliomas
- nervous tissue tumors
- oncologic disorders
- rare disease
- recurrent adult brain tumor
- Astrocytoma
- Brain Neoplasms
- Glioblastoma
- Glioma
- Oligodendroglioma
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