Phase I/II Study of Induction of Stable Mixed Chimerism After Bone Marrow Transplantation From HLA-Identical Donors in Children With Sickle Cell Disease
PROTOCOL OUTLINE: This is a multicenter study. Patients undergo total body irradiation on
day 0, followed by allogeneic bone marrow transfusion. Patients also receive fludarabine IV
daily and cyclosporine IV twice a day on days -1 to 1. Patients then receive oral
cyclosporine on days 1-90, and oral mycophenolate mofetil twice a day on days 0-27.
Patients are followed for 100 days, monthly for 6 months and then annually for 2 years.
Primary Purpose: Treatment
Children's Hospital of Oakland
|Fred Hutchinson Cancer Research Center||Seattle, Washington 98109|
|Children's Hospital of Oakland||Oakland, California 94609-1809|