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Study of Systemic Amyloidosis Presentation and Prognosis


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Amyloidosis

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Trial Information

Study of Systemic Amyloidosis Presentation and Prognosis


PROTOCOL OUTLINE: Patients receive a comprehensive evaluation with an emphasis on
identifying prognostic and diagnostic factors. Assessments include gastrointestinal, renal,
hematologic, dermatologic, cardiac, and serologic studies. Immunologic studies include
antinuclear antibody, latex fixation, and serum and urine electrophoresis.

Genetic trees are constructed using detailed family history data; blood and urine samples
are routinely collected from relatives. Family members of patients with familial
amyloidotic polyneuropathy type II (Indiana type) undergo a flexor retinaculum biopsy of the
wrist.

Inclusion Criteria


PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Systemic amyloidosis, i.e.: Primary, myeloma associated
Secondary, e.g., associated with the following conditions: Rheumatoid arthritis
Inflammatory bowel disease

Type of Study:

Observational

Study Design:

Primary Purpose: Screening

Principal Investigator

Merrill D. Benson

Investigator Role:

Study Chair

Investigator Affiliation:

Indiana University School of Medicine

Authority:

United States: Federal Government

Study ID:

NCRR-M01RR00750-0062

NCT ID:

NCT00004374

Start Date:

January 1979

Completion Date:

Related Keywords:

  • Amyloidosis
  • amyloidosis
  • arthritis & connective tissue diseases
  • genetic diseases and dysmorphic syndromes
  • rare disease
  • Amyloidosis

Name

Location

Indiana University Cancer CenterIndianapolis, Indiana  46202-5265