Phase I/II Study of High Dose Limited Volume Postoperative Reirradiation in Recurrent or Second Primary Carcinoma of the Head and Neck
- Determine the survival and local control in previously irradiated patients at high risk
for local failure following regional resection of recurrent or second primary head and
- Determine the acute and late toxicities of this treatment in these patients.
- Determine the pattern of disease failure in these patients on this treatment.
- Determine any change in quality of life in these patients on this treatment.
OUTLINE: Patients receive fractionated doses of radiotherapy five times weekly for 6 weeks.
Quality of life is assessed prior to study, 2 months after radiotherapy, every 3 months for
remainder of year 1, every 4 months for years 2-3, every 6 months for years 4-5, and then
Patients are followed 2 months after radiotherapy, every 3 months for year 1, every 4 months
for year 2, every 6 months for years 3-5, and then annually thereafter.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study within 5 years.
Primary Purpose: Treatment
James L. Pearlman, MD
H. Lee Moffitt Cancer Center and Research Institute
United States: Federal Government
|University of Alabama at Birmingham Comprehensive Cancer Center||Birmingham, Alabama 35294-3300|
|Veterans Affairs Medical Center - Tampa (Haley)||Tampa, Florida 33612|
|Loma Linda University Cancer Institute at Loma Linda University Medical Center||Loma Linda, California 92354|