Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically proven advanced or metastatic solid tumors that
have failed prior therapy and no other therapy is available At least 1 tumor mass of a
size that makes intratumoral injection feasible and biopsy or fine needle aspiration
possible Major surgery for cancer not required No lymphoma No concurrent brain metastases
(previously treated brain metastases with no evidence of recurrence allowed)

PATIENT CHARACTERISTICS: Age: 18 and over Menopausal status: Not specified Performance
status: Karnofsky 70-100% OR ECOG 0-1 Life expectancy: At least 3 months Hematopoietic:
Granulocyte count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hematocrit at
least 30% (transfusion allowed) No bleeding disorder Hepatic: Bilirubin no greater than
1.5 times upper limit of normal (ULN) ALT/AST no greater than 1.5 times ULN (3 times ULN
in the presence of liver metastases) Alkaline phosphatase no greater than 1.5 times ULN (3
times ULN in the presence of liver metastases) PT and aPTT no greater than 1.5 times ULN
No end stage liver disease Renal: Creatinine no greater than 1.5 times ULN No urinary
tract stones No end stage renal disease Cardiovascular: No known valvular disease or
ischemic peripheral vascular disease No clinically significant atherosclerotic disease or
arterial aneurysm(s) No unstable angina No active coronary artery disease requiring
medication No myocardial infarction within the past 6 months No congenital heart failure
or cardiac arrhythmia requiring medication Pulmonary: No severe oxygen-dependent chronic
obstructive pulmonary disease Other: HIV negative Not pregnant or nursing Negative
pregnancy test Fertile patients must use effective contraception Permanent central venous
catheters and other indwelling devices allowed if easily removed or replaced No gallstones
No active infection No Salmonella infection within the past 6 months No fever caused by
tumor or unknown cause (daily temperature no greater than 38 degrees C) No
immunodeficiency No other life-threatening illness No commercial food handler, day-care
worker, or health-care worker who plans to continue employment during protocol treatment
No allergy to quinolone or cephalosporin antibiotics

PRIOR CONCURRENT THERAPY: Biologic therapy: At least 6 months since any prior bone marrow
transplantation At least 4 weeks since prior biologic therapy and recovered No other
concurrent biologic therapy No prior allogeneic transplants Chemotherapy: At least 4 weeks
since prior chemotherapy (6 weeks for nitrosoureas and mitomycin) and recovered No
concurrent chemotherapy Endocrine therapy: At least 2 weeks since prior hormonal therapy
No concurrent steroids Radiotherapy: At least 4 weeks since prior radiotherapy and
recovered No concurrent radiotherapy Surgery: See Disease Characteristics At least 2 weeks
since prior surgery and recovered No artificial implant (e.g., heart valves or prosthetic
hips or knees) No prior splenectomy Other: No other concurrent antibiotics No concurrent
immunosuppressives No concurrent medications that directly or indirectly suppress the
immune system