Development of Antibody-Based Diagnostic Markers for Abnormal Cervical Cells
OBJECTIVES: I. Compare the detection of transferrin receptor, epidermal growth factor
receptor, and the MaTu-MN protein in exfoliated cervical epithelial cells from women with
abnormal Pap test using fluorescent labeled antibody probe vs histology.
OUTLINE: Patients undergo a Pap test and a colposcopy. Cervical epithelial cells are
collected from the most abnormal appearing lesion. Cells are examined for molecular markers
using a fluorescent antibody test. The presence or absence of these markers is compared to
results of the Pap test and the histology of the cells.
PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study within 6 months.
Observational Model: Cohort, Time Perspective: Cross-Sectional
Phillip Y. Roland, MD
Florida Gynecologic Oncology - Fort Myers
United States: Federal Government
|Robert H. Lurie Comprehensive Cancer Center, Northwestern University||Chicago, Illinois 60611|