Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed ovarian epithelial, peritoneal, or tubal
cancer Epithelial cell types Serous adenocarcinoma Endometrioid adenocarcinoma Mucinous
adenocarcinoma Undifferentiated carcinoma Clear cell adenocarcinoma Mixed epithelial
carcinoma Transitional cell Malignant Brenner's tumor Adenocarcinoma not otherwise
specified Measurable or evaluable disease No brain or leptomeningeal metastases No
symptomatic bowel involvement of ovarian cancer Not eligible for higher priority GOG phase
II or III study

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: GOG 0-2 Life expectancy: Not
specified Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count at
least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 times normal SGOT/SGPT/GGT no
greater than 3 times normal Alkaline phosphatase no greater than 3 times normal No acute
hepatitis Renal: Creatinine no greater than 2.0 mg/dL OR Creatinine clearance greater than
50 mL/min Other: No septicemia or severe infection Body surface area at least 1 m2
Adequate intestinal function (i.e., does not require IV hydration or nutritional support)
Not pregnant or nursing Negative pregnancy test Fertile patients must use effective
contraception 3 months prior to and during study No other malignancies within the past 5
years except curatively treated skin cancer No other severe medical problems that would
prevent compliance No condition of the GI tract that would affect GI absorption and
motility No severe gastrointestinal bleeding

PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent immunotherapy Chemotherapy: No
prior topotecan, other camptothecin analogs, or etoposide At least 1 prior
cisplatin/paclitaxel based regimen At least 3 weeks since prior chemotherapy and recovered
No more than 2 prior cytotoxic chemotherapy regimens No other concurrent chemotherapy
Endocrine therapy: No concurrent hormonal therapy for cancer Radiotherapy: At least 3
weeks since prior radiotherapy to no more than 10% of the bone marrow and recovered No
concurrent radiotherapy Surgery: Not specified Other: At least 28 days or 5 half lives
since prior investigational drugs (including cytotoxic drugs) No concurrent metoclopramide
or cisapride for maintaining gastric motility or emptying No chronic H2 antagonists,
proton pump inhibitors, or antacids for gastritis, gastroesophageal reflux disease, or
gastric or duodenal ulcers Intermittent antacids allowed, if no antacids 6 hours prior to
and 90 minutes after topotecan