Inclusion Criteria

Eligibility Criteria:

- Women with a diagnosis of breast cancer established by tissue obtained by needle
biopsy or incisional biopsy.

- There must be a residual measurable breast and/or axillary mass after biopsy.

- Clinical stage T1, N1-3, Mo or T2-4, N0-3, Mo. T2N0 lesions < 4cm in maximum
dimension are eligible only if breast conservation is not feasible or practical
without preoperative tumor shrinkage.

- Patients must be willing to undergo a mastectomy or breast sparing procedure plus
axillary lymph node dissection.

- There must be no evidence of systemic metastases.

- No prior chemotherapy. Patients may have received up to 14 days of tamoxifen. 3.1.7
Patients > 18years are eligible.

- ECOG performance status 0-1.

- Normal hematologic function defined as white blood cell count > 3500/111 or
neutrophil count > 1500411 and platelets >100,000/4

- Normal renal function defined as serum creatinine <1.5 mg/di.

- Adequate hepatic function. Bilirubin must be < institutional upper limit of normal
(ULN). Transaminases (SGOT and/or SGPT) may be up to 2.5 X institutional ULN if
alkaline phosphatase is < ULN, or alkaline phosphatase may be up to 4 X ULN if
transaminases are < ULN. However, patients who have both transaminase elevation > 1.5
X ULN and alkaline phosphatase > 2.5 X ULN are not eligible for this study (due to
decreased clearance of docetaxel and increased risk of toxicity).

- Patients with prior CIS of cervix or nonmelanoma skin cancers are eligible. Patients
with prior DCIS or LCIS of breast are eligible if not previously treated with
radiation or chemotherapy. Patients with prior malignancies including contralateral
breast cancers treated with curative intent more than 5 years before enrollment are
eligible.

- Patients must have signed informed consent.

Exclusion Criteria:

- Patients with a prior history of malignancy other than those mentioned in section
3.1.12 are ineligible.

- Patients must not have severe concurrent medical or psychiatric illness (i.e. no
severe diabetes mellitus, poorly controlled ischemic heart disease or congestive
heart failure, or severe chronic obstructive or restrictive pulmonary disease).

- The interval between initial diagnosis of breast cancer and the start of treatment
must not be greater than 8 weeks.

- Due to anticipated toxicities to an unborn fetus, and excretion of chemotherapy in
breast milk, patients must not be pregnant or lactating and must use effective
contraception during treatment.

- No history of hypersensitivity reaction to preparation containing polysorbate 80,
3.2.6 Patients must not have peripheral neuropathy grade 2 or higher.

- Patients must not have had prior radiation to >25% of bone marrow