Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically or cytologically confirmed epithelial cancer of
the exocrine pancreas Metastatic disease Previously untreated disease or progressive
disease after first-line chemotherapy Bidimensionally measurable disease Indicator lesion
must be outside of any prior radiation port No brain metastases No islet cell tumors,
lymphoma, or sarcoma of the pancreas

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: At
least 12 weeks Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count
at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL SGOT/SGPT no greater
than 2 times upper limit of normal (ULN) (5 times ULN if liver metastases present) Renal:
Creatinine no greater than 1.5 mg/dL Cardiovascular: No active congestive heart failure No
uncontrolled angina No myocardial infarction within the past 6 months Other: Not pregnant
or nursing Negative pregnancy test Fertile patients must use effective contraception No
concurrent serious infection No history of other malignancy within the past 5 years except
nonmelanoma skin cancer or carcinoma in situ of the cervix No overt psychosis, mental
disability, or incompetence No other life threatening illness

PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent biologic therapy No prophylactic
colony stimulating factors to prevent neutropenia Chemotherapy: See Disease
Characteristics At least 4 weeks since prior chemotherapy and recovered No other
concurrent cytotoxic chemotherapy Endocrine therapy: Not specified Radiotherapy: See
Disease Characteristics At least 4 weeks since prior radiotherapy and recovered No
concurrent radiotherapy Surgery: At least 4 weeks since prior major surgery and recovered
No concurrent surgery Other: No other concurrent anticancer treatment At least 28 days
since other prior investigational drugs, including analgesics or antiemetics No other
investigational drugs during and for 28 days after study No concurrent drugs that induce
or inhibit CYP3A enzyme