Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically proven ovarian, fallopian tube, or primary
peritoneal carcinoma Suboptimally debulked stage III (greater than 1.0 cm residual
disease) Stage IV Histological subtypes allowed include: Serous adenocarcinoma Mucinous
adenocarcinoma Clear cell carcinoma Transitional cell carcinoma Endometrioid
adenocarcinoma Undifferentiated adenocarcinoma Mixed epithelial adenocarcinoma
Adenocarcinoma not otherwise specified No borderline ovarian carcinoma of low malignant
potential histology Stage III disease patients must have had appropriate surgery for
ovarian, fallopian tube, and primary peritoneal carcinoma and retained suboptimally
debulked disease (greater than 1.0 cm residual disease) No CNS involvement

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: GOG 0 or 1 Life expectancy:
Not specified Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count
at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL AST and ALT no greater
than 2 times upper limit of normal Hepatitis negative Renal: Creatinine no greater than
1.5 mg/dL OR Creatinine clearance at least 60 mL/min Ureteral obstruction must be
successfully treated No renal failure Cardiovascular: No congestive heart failure No
myocardial infarction within past 6 months No significant arrhythmias requiring medication
No poorly controlled hypertension No poorly controlled systolic blood pressure No
diastolic blood pressure consistently greater than 100 mmHg Pulmonary: No significant
non-neoplastic pulmonary disease Other: No other severe medical disease HIV negative No
prior malignancy within past 5 years except squamous or basal cell carcinoma of the skin,
or carcinoma in situ of the cervix Second concurrent solid tumor malignancy allowed if not
life threatening and if does not require chemotherapy or radiotherapy No acute infection
No active peptic ulcer disease No uncontrolled diabetes mellitus No current psychiatric
disease, alcohol abuse, or drug abuse No prior hospitalization for psychiatric disease
including severe depression or psychosis Not pregnant or nursing Negative pregnancy test
Fertile patients must use effective contraception No hypersensitivity to E. coli derived
products

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior
chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to
greater than 25% of bone marrow Surgery: See Disease Characteristics No greater than 8
weeks since debulking surgery