Trial Information

The Incidence and Prognostic Significance of P16 INK4A/ P15 INK4B Gene Alterations in Children With Relapsed ALL Treated on CCG-1941

OBJECTIVES:

- Determine the incidence of p16/p15 homozygous deletions and p15 promoter
hypermethylation in acute lymphocytic leukemia cells of children treated on protocol
CCG-1941.

- Determine the prognostic importance of p16/p15 abnormalities in these children.

- Determine the presence or absence of p16/p15 abnormalities in the dominant clone at
diagnosis if present at relapse in these patients.

OUTLINE: Frozen cells are obtained from samples collected on protocol CCG-1941. DNA is
isolated and examined using Southern blot analysis to assay for deletions and promoter
hypermethylation of p16 and/or p15.

PROJECTED ACCRUAL: Approximately 100 samples will be obtained for this study.