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Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer


Phase 3
35 Years
N/A
Not Enrolling
Female
Breast Cancer

Thank you

Trial Information

Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer


OBJECTIVES:

- Determine whether raloxifene is more or less effective than tamoxifen in significantly
reducing the incidence rate of invasive breast cancer in postmenopausal women.

- Evaluate the effects of tamoxifen and raloxifene on the incidence of intraductal
carcinoma in situ, lobular carcinoma in situ, endometrial cancer, ischemic heart
disease, fractures of the hip and spine, or Colles' fractures of the wrist in these
participants.

- Evaluate the toxic effects of these regimens in these participants.

- Determine the effect of these regimens on the quality of life of these participants (at
selected centers). (Quality of life evaluation closed to accrual effective 5/31/01.)

OUTLINE: This is a randomized, double-blind study. Participants are stratified by age (35 to
49 vs 50 to 59 vs over 59), race (black vs white vs other), history of lobular carcinoma in
situ (yes vs no), prior hysterectomy (yes vs no), and estimated absolute risk of invasive
breast cancer within 5 years (using the Gail model)(less than 2.0 vs 2.0-2.9 vs 3.0-4.9 vs
5.0 or greater). Participants are randomized to 1 of 2 arms.

- Arm I: Participants receive oral tamoxifen plus placebo daily for 5 years.

- Arm II: Participants receive oral raloxifene plus placebo daily for 5 years. Quality of
life is assessed (at selected centers) at baseline and at 6, 12, 18, 24, 30, 36, 42,
48, 54, 60, and 72 months. (Quality of life evaluation closed to accrual effective
5/31/01.)

Participants are followed annually after 5 years.

PROJECTED ACCRUAL: Approximately 19,000 participants will be accrued for this study within 5
years.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Postmenopausal women at increased risk for developing invasive breast cancer, who
meet one of the following criteria:

- At least 12 months since spontaneous menstrual bleeding

- Prior documented hysterectomy and bilateral salpingo-oophorectomy

- At least 55 years of age with prior hysterectomy with or without oophorectomy

- Age 35 to 54 with a prior hysterectomy without oophorectomy OR with a status of
ovaries unknown with documented follicle-stimulating hormone level demonstrating
elevation in postmenopausal range

- Histologically confirmed lobular carcinoma in situ treated by local excision only OR
a minimum projected 5 year probability of invasive breast cancer of at least 1.66%,
using Breast Cancer Risk Assessment Profile

- No clinical evidence of malignancy on physical exam within the past 180 days

- No evidence of suspicious or malignant disease on bilateral mammogram within the past
year

- No bilateral or unilateral prophylactic mastectomy

- No prior invasive breast cancer or intraductal carcinoma in situ

- Hormone receptor status:

- Not specified

PATIENT CHARACTERISTICS:

Age:

- 35 and over

Sex:

- Female

Menopausal status:

- See Disease Characteristics

Performance status:

- No restricted normal activity for a significant portion of each day

Life expectancy:

- At least 10 years

Hematopoietic:

- Granulocyte count at least 1,500/mm^3

- Complete blood count and differential normal

- Platelet count normal

Hepatic:

- SGOT or SGPT normal

- Bilirubin normal

- Alkaline phosphatase normal

Renal:

- Creatinine normal

Cardiovascular:

- No cerebral vascular accident, transient ischemic attack, atrial fibrillation, or
uncontrolled hypertension

- No deep vein thrombosis

Pulmonary:

- No pulmonary embolus

Other:

- No other prior malignancy within the past 5 years except basal cell or squamous cell
skin cancer or carcinoma in situ of the cervix

- No concurrent nonmalignant disease that would preclude administration of tamoxifen or
raloxifene

- No clinical depression, psychiatric condition, or addictive disorder

- No uncontrolled diabetes

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- Not specified

Endocrine therapy:

- At least 3 months since prior estrogen or progesterone replacement therapy, oral
contraceptives, androgens, luteinizing hormone-releasing hormone analogs, prolactin
inhibitors, or antiandrogens

- At least 3 months since prior tamoxifen, raloxifene, or other selective
estrogen-receptor modulators of less than 3 months duration

- Concurrent Estring allowed

Radiotherapy:

- No prior breast radiotherapy

Surgery:

- See Disease Characteristics

Other:

- No prior systemic adjuvant therapy for breast cancer

- No other participation in a cancer prevention or osteoporosis prevention study
involving pharmacologic intervention(s)

- NSABP-P-1 patients who received placebo are eligible

- No concurrent warfarin or cholestyramine

- Concurrent calcitonin or nonhormonal medication (e.g., cholecalciferol, fluoride, or
bisphosphonates) allowed

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Outcome Measure:

Incidence of invasive breast cancer; superiority of one of the therapies.

Outcome Description:

Determine which of the following is true: compared to tamoxifen, raloxifene significantly reduces the incidence rate of invasive breast cancer; compared to raloxifene, tamoxifen significantly reduces the incidence rate of invasive breast cancer; or the statistical superiority of one of the treatments cannot be demonstrated and the choice of therapy should be based on benefit/risk considerations.

Outcome Time Frame:

Time from randomization to the occurance of invasive breast cancer.

Safety Issue:

No

Principal Investigator

Norman Wolmark, MD

Investigator Role:

Study Chair

Investigator Affiliation:

NSABP Foundation, Inc.

Authority:

United States: Food and Drug Administration

Study ID:

NSABP P-2

NCT ID:

NCT00003906

Start Date:

May 1999

Completion Date:

August 2012

Related Keywords:

  • Breast Cancer
  • breast cancer
  • Breast Neoplasms

Name

Location

Baylor College of MedicineHouston, Texas  77030
Suburban HospitalBethesda, Maryland  20814
Roswell Park Cancer InstituteBuffalo, New York  14263
Fred Hutchinson Cancer Research CenterSeattle, Washington  98109
Memorial Sloan-Kettering Cancer CenterNew York, New York  10021
University of Texas - MD Anderson Cancer CenterHouston, Texas  77030-4009
St. Vincent Medical Center - Los AngelesLos Angeles, California  90057
University of Michigan Comprehensive Cancer CenterAnn Arbor, Michigan  48109-0752
Mayo Clinic - JacksonvilleJacksonville, Florida  32224
Mayo Clinic Cancer CenterRochester, Minnesota  55905
Cardinal Bernardin Cancer Center at Loyola University Medical CenterMaywood, Illinois  60153-5500
Jonsson Comprehensive Cancer Center, UCLALos Angeles, California  90095-1781
H. Lee Moffitt Cancer Center and Research InstituteTampa, Florida  33612
MBCCOP - HawaiiHonolulu, Hawaii  96813
University of Chicago Cancer Research CenterChicago, Illinois  60637
Barbara Ann Karmanos Cancer InstituteDetroit, Michigan  48201
Duke Comprehensive Cancer CenterDurham, North Carolina  27710
Cleveland Clinic Cancer CenterCleveland, Ohio  44195
Ireland Cancer CenterCleveland, Ohio  44106-5065
Arthur G. James Cancer Hospital - Ohio State UniversityColumbus, Ohio  43210
Abington Memorial HospitalAbington, Pennsylvania  19001
Fox Chase Cancer CenterPhiladelphia, Pennsylvania  19111
CCOP - Upstate CarolinaSpartanburg, South Carolina  29303
CCOP - WichitaWichita, Kansas  67214-3882
Hurley Medical CenterFlint, Michigan  48503
Presbyterian HealthcareCharlotte, North Carolina  28233-3549
Rhode Island HospitalProvidence, Rhode Island  02903
University of Texas Health Science Center at San AntonioSan Antonio, Texas  78284-7811
CCOP - Atlanta RegionalAtlanta, Georgia  30342-1701
CCOP - Kansas CityKansas City, Missouri  64131
CCOP - Southern Nevada Cancer Research FoundationLas Vegas, Nevada  89106
CCOP - Christiana Care Health ServicesWilmington, Delaware  19899
CCOP - Mount Sinai Medical CenterMiami Beach, Florida  33140
CCOP - North Shore University HospitalManhasset, New York  11030
CCOP - Southeast Cancer Control ConsortiumWinston-Salem, North Carolina  27104-4241
MBCCOP - Massey Cancer CenterRichmond, Virginia  23298-0037
CCOP - Illinois Oncology Research AssociationPeoria, Illinois  61602
CCOP - Carle Cancer CenterUrbana, Illinois  61801
CCOP - Iowa Oncology Research AssociationDes Moines, Iowa  50309-1016
Beth Israel Deaconess Medical CenterBoston, Massachusetts  02215
CCOP - KalamazooKalamazoo, Michigan  49007-3731
CCOP - Metro-MinnesotaSaint Louis Park, Minnesota  55416
CCOP - Northern New JerseyHackensack, New Jersey  07601
Bergan Mercy Medical CenterOmaha, Nebraska  68124
St. Vincent Hospital and Health Care CenterIndianapolis, Indiana  46260
Yale Comprehensive Cancer CenterNew Haven, Connecticut  06520-8028
Hinsdale Hematology Oncology AssociatesHinsdale, Illinois  60521
Methodist Cancer Center at Methodist HospitalIndianapolis, Indiana  46202
Saint Anthony Memorial Health CentersMichigan City, Indiana  46360
CCOP - Michigan Cancer Research ConsortiumAnn Arbor, Michigan  48106
St. John Macomb HospitalWarren, Michigan  48093
CCOP - DuluthDuluth, Minnesota  55805
Hennepin County Medical Center - MinneapolisMinneapolis, Minnesota  55415
Geisinger Medical CenterDanville, Pennsylvania  17822-0001
Penn State Cancer Institute at Milton S. Hershey Medical CenterHershey, Pennsylvania  17033-0850
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical CenterLa Crosse, Wisconsin  54601
Medical College of Wisconsin Cancer CenterMilwaukee, Wisconsin  53226
Fox Chase - Temple Cancer CenterPhiladelphia, Pennsylvania  19111-2442
MD Anderson Cancer Center OrlandoOrlando, Florida  32806
CCOP - Cedar Rapids Oncology ProjectCedar Rapids, Iowa  52403-1206
Siouxland Hematology-OncologySioux City, Iowa  51101-1733
CCOP - OchsnerNew Orleans, Louisiana  70121
Massachusetts General Hospital Cancer CenterBoston, Massachusetts  02114
CCOP - Merit Care HospitalFargo, North Dakota  58122
Rapid City Regional HospitalRapid City, South Dakota  57709
CCOP - Sioux Community Cancer ConsortiumSioux Falls, South Dakota  57105-1080
Comprehensive Cancer Center at Wake Forest UniversityWinston-Salem, North Carolina  27157-1082
NYU School of Medicine's Kaplan Comprehensive Cancer CenterNew York, New York  10016
Huntsman Cancer InstituteSalt Lake City, Utah  84112
Providence Saint Joseph Medical Center - BurbankBurbank, California  91505
Mount Diablo Medical CenterConcord, California  94524-4110
Kaiser Permanente Medical Center - Los AngelesLos Angeles, California  90027
CCOP - Santa Rosa Memorial HospitalSanta Rosa, California  95403
Northwest Community HospitalArlington Heights, Illinois  60005
Northwestern Memorial HospitalChicago, Illinois  60611
Ingalls Memorial HospitalHarvey, Illinois  60426
Lutheran General Cancer Care CenterPark Ridge, Illinois  60068
CCOP - Central IllinoisSpringfield, Illinois  62526
Wendt Regional Cancer Center of Finley HospitalDubuque, Iowa  52001
Greater Baltimore Medical Center and Cancer CenterBaltimore, Maryland  21204
Marquette General HospitalMarquette, Michigan  49855
CCOP - Cancer Research for the OzarksSpringfield, Missouri  65807
CCOP - Montana Cancer ConsortiumBillings, Montana  59101
Newark Beth Israel Medical CenterNewark, New Jersey  07112
Community Medical CenterToms River, New Jersey  08755
Akron General Medical CenterAkron, Ohio  44302
CCOP - ColumbusColumbus, Ohio  43206
CCOP - DaytonKettering, Ohio  45429
Delaware County Memorial HospitalDrexel Hill, Pennsylvania  19026
Albert Einstein Cancer CenterPhiladelphia, Pennsylvania  19141
Reading Hospital and Medical CenterReading, Pennsylvania  19612-6052
Grand View HospitalSellersville, Pennsylvania  18960
Harrington Cancer CenterAmarillo, Texas  79106
Joe Arrington Cancer Research and Treatment CenterLubbock, Texas  79410-1894
Green Mountain Oncology GroupRutland, Vermont  05701
Martha Jefferson HospitalCharlottesville, Virginia  22901
University of Wisconsin Comprehensive Cancer CenterMadison, Wisconsin  53792
CCOP - Western Regional, ArizonaPhoenix, Arizona  85006-2726
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer CenterOrange, California  92868
MBCCOP - University of Illinois at ChicagoChicago, Illinois  60612
CCOP - EvanstonEvanston, Illinois  60201
CCOP - Northern Indiana CR ConsortiumSouth Bend, Indiana  46601
Holden Comprehensive Cancer Center at University of IowaIowa City, Iowa  52242-1002
CCOP - Grand RapidsGrand Rapids, Michigan  49503
Keesler Medical Center - Keesler Air Force BaseKeesler AFB, Mississippi  39534-2576
Ellis Fischel Cancer Center at University of Missouri - ColumbiaColumbia, Missouri  65203
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel HillChapel Hill, North Carolina  27599-7570
Charles M. Barrett Cancer Center at University HospitalCincinnati, Ohio  45267-0526
CCOP - Columbia River Oncology ProgramPortland, Oregon  97225
Kimmel Cancer Center at Thomas Jefferson University - PhiladelphiaPhiladelphia, Pennsylvania  19107
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical CenterNashville, Tennessee  37232-2516
CCOP - Scott and White HospitalTemple, Texas  76508
Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimore, Maryland  21231-2410
Baptist Regional Cancer Institute - JacksonvilleJacksonville, Florida  32207
St. Barnabas Medical CenterLivingston, New Jersey  07039
Kaiser Permanente Center for Health ResearchPortland, Oregon  97227-1098
Cleveland Clinic Taussig Cancer CenterCleveland, Ohio  44195
MBCCOP - Gulf CoastMobile, Alabama  36688
USC/Norris Comprehensive Cancer Center and HospitalLos Angeles, California  90033-0804
MBCCOP - LSU Health Sciences CenterNew Orleans, Louisiana  70112
CCOP - St. Louis-Cape GirardeauSaint Louis, Missouri  63141
CCOP - Virginia Mason Research CenterSeattle, Washington  98101
CCOP - NorthwestTacoma, Washington  98405-0986
Naval Medical Center - San DiegoSan Diego, California  92134-3202
Kaiser Permanente Medical Center - VallejoVallejo, California  94589
Hartford HospitalHartford, Connecticut  06102-5037
Rockford ClinicRockford, Illinois  61103
Baptist Hospital East - LouisvilleLouisville, Kentucky  40207
Eastern Maine Medical CenterBangor, Maine  04401
Franklin Square Hospital CenterBaltimore, Maryland  21237
Genesee Surgical AssociatesRochester, New York  14607
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.Syracuse, New York  13217
CCOP - OklahomaTulsa, Oklahoma  74136
Allegheny General HospitalPittsburgh, Pennsylvania  15212-4772
University of Texas Health Center at TylerTyler, Texas  75708
Virginia Oncology Associates - Newport NewsNewport News, Virginia  23606
Oncology and Hematology Associates of Southwest Virginia, Inc.Roanoke, Virginia  24014
Camden-Clark Memorial HospitalParkersburg, West Virginia  26102
Providence Alaska Medical CenterAnchorage, Alaska  99508
Monmouth Medical CenterLong Branch, New Jersey  07740-6395
South Jersey Regional Cancer CenterMillville, New Jersey  08332
Cancer Institute of New JerseyNew Brunswick, New Jersey  08901
Atlantic City Medical CenterPomona, New Jersey  08240
St. John Health SystemTulsa, Oklahoma  74104
Hunterdon Regional Cancer CenterFlemington, New Jersey  08822
Rebecca and John Moores UCSD Cancer CenterLa Jolla, California  92093-0658
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San DiegoSan Diego, California  92120
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer InstituteBoston, Massachusetts  02115
University of Massachusetts Memorial Medical Center - University CampusWorcester, Massachusetts  01655
St. John Hospital and Medical CenterDetroit, Michigan  48236
University of New Mexico Cancer Research and Treatment CenterAlbuquerque, New Mexico  87131
City of Hope Comprehensive Cancer CenterDuarte, California  91010
UCSF Comprehensive Cancer CenterSan Francisco, California  94115
Saint Anthony Medical CenterRockford, Illinois  61108
Albert Einstein Clinical Cancer CenterBronx, New York  10461
Queens Cancer Center of Queens HospitalJamaica, New York  11432
Cape Fear Valley Health SystemFayetteville, North Carolina  28302-2000
New Hanover Regional Medical CenterWilmington, North Carolina  28402-9025
Cooper Cancer InstituteCamden, New Jersey  08103
Capital Health System at MercerTrenton, New Jersey  08607
CCOP - BeaumontRoyal Oak, Michigan  48073-6769
St. Vincent Mercy Medical CenterToledo, Ohio  43608
CCOP - Colorado Cancer Research Program, IncorporatedDenver, Colorado  80224
Hillman Cancer Center at University of Pittsburgh Cancer InstitutePittsburgh, Pennsylvania  15236
Arizona Cancer Center at University of Arizona Health Sciences CenterTucson, Arizona  85724
Arkansas Cancer Research Center at University of Arkansas for Medical SciencesLittle Rock, Arkansas  72205
Kansas Masonic Cancer Research Institute at the University of Kansas Medical CenterKansas City, Kansas  66160-7353
Markey Cancer Center at University of Kentucky Chandler Medical CenterLexington, Kentucky  40536-0084
Tulane Cancer Center at Tulane University Hospital and ClinicNew Orleans, Louisiana  70112
Cancer Research Center at Boston Medical CenterBoston, Massachusetts  02118
Josephine Ford Cancer Center at Henry Ford HospitalDetroit, Michigan  48202
Herbert Irving Comprehensive Cancer Center at Columbia UniversityNew York, New York  10032
Cancer Institute at Oregon Health and Science UniversityPortland, Oregon  97201-3098
Swedish Cancer Institute at Swedish Medical Center - First Hill CampusSeattle, Washington  98104
Palmetto Richland Memorial HospitalColumbia, South Carolina  29203
Thompson Cancer Survival CenterKnoxville, Tennessee  37916
Northeast Arkansas ClinicJonesboro, Arkansas  72401-3125
James Graham Brown Cancer Center at University of LouisvilleLouisville, Kentucky  40202
Maine Center for Cancer Medicine and Blood Disorders - ScarboroughScarborough, Maine  04074
Blumenthal Cancer Center at Carolinas Medical CenterCharlotte, North Carolina  28232-2861
Charles A. Sammons Cancer CenterDallas, Texas  75246
St. John's Regional Health CenterSpringfield, Missouri  65804
Comprehensive Cancer Centers of the DesertPalm Springs, California  92262
North Idaho Cancer CenterCoeur d'Alene, Idaho  83814
Stanford Cancer Center at Stanford University Medical CenterStanford, California  94305
Hospital of St. RaphaelNew Haven, Connecticut  06511
Central Baptist HospitalLexington, Kentucky  40503
Fox Chase Virtua Health Cancer Program at Virtua Memorial HospitalMount Holly, New Jersey  08060
Valley HospitalRidgewood, New Jersey  07450
Vassar Brothers Medical CenterPoughkeepsie, New York  12601
CCOP - Toledo Community HospitalToledo, Ohio  43623-3456
St. Luke's Hospital Cancer CenterBethlehem, Pennsylvania  18015
Mercy Fitzgerald HospitalDarby, Pennsylvania  19023
Wilford Hall Medical CenterLackland Air Force Base, Texas  78236-5300
Waukesha Memorial Hospital Regional Cancer CenterWaukesha, Wisconsin  53188
New Britain General HospitalNew Britain, Connecticut  06050
Loma Linda University Cancer Institute at Loma Linda University Medical CenterLoma Linda, California  92354
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical CenterSavannah, Georgia  31403-3089
Advocate Christ Medical CenterOak Lawn, Illinois  60453
Toledo HospitalToledo, Ohio  43606
Hollings Cancer Center at Medical University of South CarolinaCharleston, South Carolina  29425
Lahey Clinic Medical Center - BurlingtonBurlington, Massachusetts  01805
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - OmahaOmaha, Nebraska  68114-4199
Aultman Hospital Cancer Center at Aultman Health FoundationCanton, Ohio  44710-1799
Wellspan Health - York Cancer CenterYork, Pennsylvania  17403
CCOP - Marshfield Clinic Research FoundationMarshfield, Wisconsin  54449
James P. Wilmot Cancer Center at University of Rochester Medical CenterRochester, New York  14642
Warren HospitalPhillipsburg, New Jersey  08865
Chester County HospitalWest Chester, Pennsylvania  19380
Comprehensive Cancer InstituteHuntsville, Alabama  35801
Torrance Memorial Medical CenterTorrance, California  90505
Oncology Institute of Greater LafayetteLafayette, Indiana  47904
St. Elizabeth Medical CenterEdgewood, Kentucky  41017
NSMC Cancer CenterPeabody, Massachusetts  01960
Somerset Medical CenterSomerville, New Jersey  08876
Cancer Center at Christ HospitalCincinnati, Ohio  45219
Parma Community General HospitalParma, Ohio  44129
Vermont Cancer Center at University of VermontBurlington, Vermont  05405-0075
Holland Community HospitalHolland, Michigan  49423
Munson Medical CenterTraverse City, Michigan  49684
Kalispell Regional Medical CenterKalispell, Montana  59901
St. Joseph Hospital Community Cancer CenterBellingham, Washington  98225
Olympic Hematology and OncologyBremerton, Washington  98310
Lombardi Cancer Center at Georgetown University Medical CenterWashington, District of Columbia  20007
Greenebaum Cancer Center at University of Maryland Medical CenterBaltimore, Maryland  21201
New Hampshire Oncology-Hematology, PA - HooksettHooksett, New Hampshire  03106
Swedish-American Regional Cancer CenterRockford, Illinois  61104-2315
University of Connecticut Comprehensive Cancer Center at University of Connecticut Health CenterFarmington, Connecticut  06360-7106
Baystate Regional Cancer Program at Baystate Medical CenterSpringfield, Massachusetts  01107
University Hospital at State University of New York - Upstate Medical UniversitySyracuse, New York  13210
Mission HospitalsAsheville, North Carolina  28801
Leo W. Jenkins Cancer Center of University Health Systems of Eastern CarolinaGreenville, North Carolina  27858-4354
Simmons Cancer Center at University of Texas Southwestern Medical Center - DallasDallas, Texas  75390-9063
Abramson Cancer Center at University of Pennsylvania Medical CenterPhiladelphia, Pennsylvania  19104
Robert H. Lurie Comprehensive Cancer Center at Northwestern UniversityChicago, Illinois  60611
Cancer Center of Santa BarbaraSanta Barbara, California  93105
Rockwood Clinic P.S.Spokane, Washington  99202
St. Francis Hospital and Medical CenterHartford, Connecticut  06105
Todd Cancer Institute at Long Beach Memorial Medical CenterLong Beach, California  90801
Saint Vincent Catholic Medical Center of New YorkNew York, New York  10011
Lakeland Regional Cancer Center at Lakeland Regional Medical CenterLakeland, Florida  33805
Alta Bates Comprehensive Cancer CenterBerkeley, California  94704
North Bay Cancer CenterFairfield, California  94533
California Pacific Medical Center - California CampusSan Francisco, California  94118
Poudre Valley HospitalFort Collins, Colorado  80524
St. Mary-Corwin Regional Medical CenterPueblo, Colorado  81004
Beebe Medical CenterLewes, Delaware  19958
Ella Milbank Foshay Cancer Center at Jupiter Medical CenterJupiter, Florida  33458
Edward Hospital Cancer CenterNaperville, Illinois  60540
Genesis Regional Cancer Center at Genesis Medical CenterDavenport, Iowa  52803
Ochsner Clinic of Baton RougeBaton Rouge, Louisiana  708169990
Hickman Cancer Center at Bixby Medical CenterAdrian, Michigan  49221
Hattiesburg Clinic, P.A.Hattiesburg, Mississippi  39401
Creighton University Medical CenterOmaha, Nebraska  68131-2197
Booker Cancer Center at Riverview Medical CenterRed Bank, New Jersey  07701
Blanchard Valley Medical AssociatesFindlay, Ohio  45840
Fremont Memorial HospitalFremont, Ohio  43420
Lima Memorial HospitalLima, Ohio  45804
St. Luke's HospitalMaumee, Ohio  43537
Firelands Regional Medical CenterSandusky, Ohio  44870
Mercy Medical CenterSpringfield, Ohio  45504
Fulton County Health CenterWauseon, Ohio  43567
Bryn Mawr HospitalBryn Mawr, Pennsylvania  19010
Lankenau Cancer Center at Lankenau HospitalWynnewood, Pennsylvania  19096
Southwestern Vermont Regional Cancer CenterBennington, Vermont  05201
Mountainview MedicalBerlin, Vermont  05602
Kaiser Permanente Medical GroupLos Angeles, California  90027
Penrose Cancer CenterColorado Springs, Colorado  80933
Lawrence and Memorial HospitalNew London, Connecticut  06320
Northwestern Connecticut Oncology-Hematology AssociatesTorrington, Connecticut  06790
Edward H. Kaplan MD and AssociatesSkokie, Illinois  60076
McFarland Clinic, P.C.Ames, Iowa  50010
Ottumwa Regional Health CenterOttumwa, Iowa  52501
Anne Arundel Medical CenterAnnapolis, Maryland  21401
Rice Memorial HospitalWillmar, Minnesota  56201
Alegent Health - Immanuel Medical CenterOmaha, Nebraska  68122
St. Charles HospitalOregon, Ohio  43616
Lancaster General HospitalLancaster, Pennsylvania  17604-3555
Pottstown Memorial Regional Cancer CenterPottstown, Pennsylvania  19464
UW Cancer Center Wausau HospitalWausau, Wisconsin  54401
CCOP - Mayo Clinic Scottsdale Oncology ProgramScottsdale, Arizona  85259
Mills-Peninsula Health ServicesBurlingame, California  94010
Leavey Cancer Center at Northridge Hospital Medical CenterNorthridge, California  91325
Palo Alto Medical FoundationPalo Alto, California  94301
Creticos Cancer Center at Advocate Illinois Masonic Medical CenterChicago, Illinois  60657
Mercy Cancer Center at Mercy Medical Center - North IowaMason City, Iowa  50401
Battle Creek Health SystemBattle Creek, Michigan  49017
Saint Luke's HospitalChesterfield, Missouri  63017
Missouri Baptist Cancer CenterSt. Louis, Missouri  63131
Cancer Center at the Good Samaritan Health SystemsKearney, Nebraska  68847
Cancer Resource Center - LincolnLincoln, Nebraska  68510
Hematology-Oncology Associates, PCAlbuquerque, New Mexico  87106
Lovelace Medical Center at Lovelace Sandia Health SystemAlbuquerque, New Mexico  87108
Louis Busch Hager Cancer Center at Mary Imogene Bassett HospitalCooperstown, New York  13326
Moses Cone Regional Cancer Center at Wesley Long Community HospitalGreensboro, North Carolina  27401
Medical College of Ohio Cancer InstituteToledo, Ohio  43614
Toledo Clinic, IncorporatedToledo, Ohio  43623
John and Dorothy Morgan Cancer Center at Lehigh Valley HospitalAllentown, Pennsylvania  18105
Cancer Center at Paoli Memorial HospitalPaoli, Pennsylvania  19301
Eastern Connecticut Hematology and Oncology AssociatesNorwich, Connecticut  06360
Scripps Memorial Hospitals-Stevens Cancer Center - EncinitasEncinitas, California  92023
Oklahoma University Medical Center at University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma  73126
University of MinnesotaMinneapolis, Minnesota  55455
Palm Beach Cancer InstituteWest Palm Beach, Florida  33401
Providence Cancer Institute at Providence HospitalSouthfield, Michigan  48075
University of Miami Sylvester Cancer CenterMiami, Florida  33136
John H. Stroger, Jr. Hospital of Cook CountyChicago, Illinois  60612-9985
Community HospitalMunster, Indiana  46321
Norton Healthcare Cancer CenterLouisville, Kentucky  40202-5070
New York Oncology Hematology, P.C. - Albany Regional Cancer CenterAlbany, New York  12208
Charles R. Wood Foundation Cancer Center at Glens Falls HospitalGlens Falls, New York  12801
Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - MemphisMemphis, Tennessee  38146
Sutter Breast Cancer GroupSacramento, California  95819-5156
Huntington Cancer Center at Huntington HospitalPasadena, California  91105
St. John's HospitalSpringfield, Illinois  62701
Watson ClinicLakeland, Florida  33805
Baton Rouge General Medical CenterBaton Rouge, Louisiana  70821-2511
Genesys Regional Medical CenterGrand Blanc, Michigan  48439-8066
Sacred Heart HospitalAllentown, Pennsylvania  18102
Aurora Sinai Medical CenterMilwaukee, Wisconsin  53201-0342
St. Joseph Hospital Regional Cancer Center - OrangeOrange, California  92868-3849
Southern New Hampshire Medical CenterNashua, New Hampshire  03061-2014
Comprehensive Cancer Center at Our Lady of Mercy Medical CenterBronx, New York  10466
Flower Hospital - ProMedica Health SystemSylvania, Ohio  43560
Easton HospitalEaston, Pennsylvania  18042
Southwest Cancer and Research Center at University Medical CenterLubbock, Texas  79415-3364
Enloe Cancer Center at Enloe Medical CenterChico, California  95926
Caritas Norwood HospitalNorwood, Massachusetts  02062
Pardee Memorial HospitalHendersonville, North Carolina  28791
Bethesda North HospitalCincinnati, Ohio  45242
Community Cancer Center at Rutland Regional Medical CenterRutland, Vermont  05701
Ball Memorial Hospital Cancer CenterMuncie, Indiana  47303-3499
Regional Cancer Center - ErieErie, Pennsylvania  16505
Siteman Cancer CenterSaint Louis, Missouri  63110
Breast AssociatesFayetteville, Arkansas  72703
Surgical AssociatesFort Smith, Arkansas  72917
Kaiser Permanente Medical Center - Anaheim/Orange CountyAnaheim, California  92805
Kaiser Permanente Medical Center - Baldwin ParkBaldwin Park, California  91706
Kaiser Permanente Medical Center - BellflowerBellflower, California  90706
Corona Regional Medical CenterCorona, California  92882-3400
Kaiser Permanente Medical Center - FontanaFontana, California  92335
Crosson Cancer Center at St. Jude Medical CenterFullerton, California  92835
Glendale Memorial Hospital Comprehensive Cancer CenterGlendale, California  91204
Oncology/Hematology AssociatesGranada Hills, California  91344
Marin General Hospital Cancer InstituteGreenbrae, California  94904
Kaiser Permanente Medical Center - Harbor CityHarbor City, California  90710
Hemet Valley Medical CenterHemet, California  92543
Valley Tumor Medical GroupLancaster, California  93534
Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long BeachLong Beach, California  90813
Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical CenterLos Angeles, California  90033
Kaiser Foundation Hospital - West Los AngelesLos Angeles, California  90034
Mission Cancer Center at Mission HospitalMission Viejo, California  92691
Sutter Gould Medical FoundationModesto, California  95353
Breast Health CenterOceanside, California  92056
Ventura Hematology - Oncology Specialists - OxnardOxnard, California  93030
Wilshire Oncology Medical Group, Incorporated - PomonaPomona, California  91767-3021
North Valley Breast ClinicRedding, California  96001
Kaiser Permanente Medical Center - RiversideRiverside, California  92505
Sutter Roseville Medical CenterRoseville, California  95661
Santa Clarita Valley Cancer Center - UCLAValencia, California  91355
Kaiser Permanente Medical Cener - Woodland HillsWoodland Hills, California  91365-4084
Manchester Memorial HospitalManchester, Connecticut  06040-4188
Midstate Medical CenterMeriden, Connecticut  06451
Hematology Oncology, P.C.Stamford, Connecticut  06902
Windham Community Memorial HospitalWilliamantic, Connecticut  06226
Nanticoke Memorial HospitalSeaford, Delaware  19973
Providence HospitalWashington, District of Columbia  20017
Washington Hospital CenterWashington, District of Columbia  20010
JFK Medical CenterAtlantis, Florida  33462
St. Vincent's Medical CenterJacksonville, Florida  32203
Florida Hospital Medical CenterOrlando, Florida  32803-1273
West Florida Regional Medical CenterPensacola, Florida  32514-6088
Cancer Research Network Inc.Plantation, Florida  33324
Clinical Research Center of South FloridaStuart, Florida  34996
Medical College of GeorgiaAugusta, Georgia  30912
Cancer Care and Research Pavilion at St. Joseph's/CandlerSavannah, Georgia  31405-6013
Rush Copley Medical CenterAurora, Illinois  60504-4206
Our Lady of the Resurrection Medical CenterChicago, Illinois  60634
Rush Cancer Institute at Rush University Medical CenterChicago, Illinois  60612
Resurrection Medical CenterChicago, Illinois  60631
Sherman HospitalElgin, Illinois  60120-2198
St. Francis HospitalEvanston, Illinois  60202
Advocate South Suburban HospitalHazel Crest, Illinois  60429
Evanston Northwestern Health Care - Highland Park HospitalHighland Park, Illinois  60035-2497
Joliet Oncology Hematology Associates, Limited - JolietJoliet, Illinois  60435
Mid-Illinois Hematology-Oncology AssociatesNormal, Illinois  61761
Saint James Hospital and Health Centers Comprehensive Cancer InstituteOlympia Fields, Illinois  60461
Trinity Medical Center - WestRock Island, Illinois  61201
Memorial Medical CenterSpringfield, Illinois  62781
Center for Cancer Care at Goshen Health SystemGoshen, Indiana  46526
Indiana Regional Cancer CenterIndianapolis, Indiana  46256
Indiana Community Cancer Care, IncorporatedIndianapolis, Indiana  46202
Medical AssociatesClinton, Iowa  52732-5031
Jennie Edmundson Memorial HospitalCouncil Bluffs, Iowa  51503
Cedar Valley Medical Specialists, P.C.Waterloo, Iowa  50701
King's Daughters Medical CenterAshland, Kentucky  41101
HCA Kings Daughters Memorial HospitalFrankfort, Kentucky  40601
Cancer Care SpecialistsHouma, Louisiana  70360
Cancer Treatment Center at Christus Schumpert St. Mary PlaceShreveport, Louisiana  71101
Goodall HospitalSanford, Maine  04073
Frederick Memorial Hospital Regional Cancer Therapy CenterFrederick, Maryland  21701
Harvard Vanguard Medical Associates - KenmoreBoston, Massachusetts  02215
Saint Anne's HospitalFall River, Massachusetts  02721
Berkshire Physicians and Surgeons, P.C.Pittsfield, Massachusetts  01201
Jordan Hospital Club Cancer CenterPlymouth, Massachusetts  02360
Bay Diagnostic Center for WomenBay City, Michigan  48708
Community Health Center of Branch CountyColdwater, Michigan  49036
Oakwood Hospital and Medical CenterDearborn, Michigan  48123-2500
Flint Hematology OncologyFlint, Michigan  48532
Center for Hematology/OncologyJackson, Michigan  49201
Michigan State University Department of SurgeryLansing, Michigan  48912
Lapeer Regional HospitalLapeer, Michigan  48446
Mercy Memorial Hospital, CorporationMonroe, Michigan  48161-0067
Community Cancer Care SpecialistMount Clemens, Michigan  48043
Memorial HealthcareOwosso, Michigan  48867
Blue Water Oncology PC, Port HuronPort Huron, Michigan  48060
Saint Mary's Seton Cancer InstituteSaginaw, Michigan  48601
St. Luke's Medical ClinicDuluth, Minnesota  55805
Minnesota Cooperative Group ProgramMinneapolis, Minnesota  55407
Coast Oncology/Hematology, P.L.L.C.Biloxi, Mississippi  39530-4239
Mid Delta Family PracticeCleveland, Mississippi  38732
Jackson Oncology Associates, PLLCJackson, Mississippi  39202
North Mississippi Hematology and Oncology Associates, LimitedTupelo, Mississippi  38801
St. John's Regional Medical CenterJoplin, Missouri  64804
Freeman Cancer Institute at Freeman Health SystemJoplin, Missouri  64803-2644
Phelps County Regional Medical CenterRolla, Missouri  65401
Midwest Hematology Oncology Group, Inc.Saint Louis, Missouri  63109
Missouri Cancer Care, P.C. - St. CharlesSt. Charles, Missouri  63301
Ozarks Medical CenterWest Plains, Missouri  65775
Montana Cancer Institute - Benefis HealthcareGreat Falls, Montana  59405
Saint Francis Medical CenterGrand Island, Nebraska  68802
Englewood Hospital and Medical CenterEnglewood, New Jersey  07631
Underwood Memorial HospitalWoodbury, New Jersey  08096
New Mexico Oncology-Hematology Consultants, LimitedAlbuquerque, New Mexico  87109
New Mexico Cancer Care AssociatesSanta Fe, New Mexico  87505-7670
New York Oncology Hematology, P.C. - LathamLatham, New York  12110-0610
St. Francis Hospital and Health CentersPoughkeepsie, New York  12601
Gynecologic Oncology AssociatesRochester, New York  14620
University Hospital - Stony BrookStony Brook, New York  11794-8174
Gaston Hematology and OncologyGastonia, North Carolina  28054
Southeastern Medical Oncology CenterGoldsboro, North Carolina  27534
Cornerstone SurgeryHigh Point, North Carolina  27262
Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer CenterRaleigh, North Carolina  27607
Cancer Center at Iredell Memorial HospitalStatesville, North Carolina  28687-1828
Forsyth Medical CenterWinston-Salem, North Carolina  27103
Quain & Ramstad ClinicBismarck, North Dakota  58501
Kaiser PermanenteCleveland, Ohio  44120
Fairview HospitalCleveland, Ohio  44111
Cleveland Clinic Health System STAR BCPTWarrensville Heights, Ohio  44122
Muskogee Regional Medical CenterMuskogee, Oklahoma  74401
Frank C. Love Cancer Institute at St. Anthony HospitalOklahoma City, Oklahoma  73101
Mercy Health CenterOklahoma City, Oklahoma  73120
Central Oklahoma Cancer Center at INTEGRIS Southwest Medical CenterOklahoma City, Oklahoma  73109
St. Charles Medical CenterBend, Oregon  97701
Bon Secours-Holy Family Health SystemAltoona, Pennsylvania  16602
Doylestown HospitalDoylestown, Pennsylvania  18901
Ephrata Community HopitalEphrata, Pennsylvania  17522-1002
Pinnacle Health Regional Cancer Center at Pinnacle Health SystemHarrisburg, Pennsylvania  17105-8700
Mercy Community HospitalHavertown, Pennsylvania  19083
Saint Mary Regional Cancer CenterLanghorne, Pennsylvania  19047
Riddle Memorial HospitalMedia, Pennsylvania  19063
Mercy Hospital of PhiladelphiaPhiladelphia, Pennsylvania  19143
Chestnut Hill HealthcarePhiladelphia, Pennsylvania  19118
Frankford HospitalPhiladelphia, Pennsylvania  19114
Pennsylvania Oncology Hematology AssociatesPhiladelphia, Pennsylvania  19107
Crozer-Chester Medical CenterUpland, Pennsylvania  19013
AnMed HealthAnderson, South Carolina  29621
Roper St. Francis Healthcare - Roper HospitalCharleston, South Carolina  29401
McLeod Regional Medical CenterFlorence, South Carolina  29501
Cancer Centers of the Carolinas - EastsideGreenville, South Carolina  29601
Wellmont Holston Valley Hospital and Medical CenterKingsport, Tennessee  37662
U.T. Cancer Institute at University of Tennessee Medical CenterKnoxville, Tennessee  37920-2911
MBCCOP - Meharry Medical College - NashvilleNashville, Tennessee  37208-3599
Hendrick Cancer CenterAbilene, Texas  79601-2316
Julie and Ben Rogers Cancer CenterBeaumont, Texas  77701
Methodist Dallas Medical CenterDallas, Texas  75265-5999
Presbyterian Hospital of DallasDallas, Texas  75231
Providence Memorial HospitalEl Paso, Texas  79902
Harris Methodist Fort WorthFort Worth, Texas  76104
Texas Cancer Institute at St. Luke's Episcopal HospitalHouston, Texas  77030
Baylor Medical Center at GarlandIrving, Texas  75061
Sanchez Cancer CenterLaredo, Texas  78041
Memorial Health System of East TexasLufkin, Texas  75902
Baylor/Richardson Cancer CenterRichardson, Texas  75080
Danville Hematology and Oncology, IncorporatedDanville, Virginia  24541
Cancer Center of the Piedmont, Inc.Danville, Virginia  24541
Henrico Doctors' Hospital - Parham CampusRichmond, Virginia  23229
Flynn Cancer Center at Providence Everett Medical Center - Pacific CampusEverett, Washington  98258-0000
Cancer Care Northwest - Spokane NorthSpokane, Washington  99207
Yakima Regional Cancer Care CenterYakima, Washington  89802
David Lee Cancer Center at Charleston Area Medical CenterCharleston, West Virginia  25304-1297
Oncology Alliance, S.C.Milwaukee, Wisconsin  53215