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Molecular Genetic Features of Acute Lymphoblastic Leukemia

18 Years
Open (Enrolling)

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Trial Information

Molecular Genetic Features of Acute Lymphoblastic Leukemia


- Perform quantitative polymerase chain reaction (PCR) using known leukemia specific
markers in diagnostic bone marrow specimens and correlate pre-treatment copy number
with other biologic and molecular features, clinical response, and treatment outcomes
of patients with previously untreated acute lymphoblastic leukemia (ALL) or acute
promyelocytic leukemia (APL).

- Evaluate the expression of novel genes or microRNAs implicated in disease pathogenesis
and treatment response in pretreatment blood and bone marrow specimens of these
patients and correlate these findings with other biological features and treatment

- Evaluate the clinical significance of sequential quantitative MRD measurements using
real-time quantitative PCR and/or flow cytometry during and following treatment and
correlate these findings with efficacy of novel treatment approaches and other
biological and clinical prognostic features.

- Compare the measurement of MRD in blood with bone marrow specimens in sequential
remission specimens.

OUTLINE: Blood and bone marrow samples are collected from patients periodically.

Samples are examined for the p190 and p210 BCR-ABL and WT-1 transcripts using reverse
transcriptase-polymerase chain reaction (RT-PCR) analysis of the DNA and for marginal
residual disease (MRD) via flow cytometric analysis.

Patients do not receive the results of the genetic testing and the results do not influence
the type or duration of treatment.

PROJECTED ACCRUAL: A total of 450 patients will be accrued for this study over 5 years.

Inclusion Criteria


- Diagnosis of 1 of the following diseases:

- Acute lymphoblastic leukemia (ALL)

- Patients enrolled on CALGB-19802 or any CALGB treatment trials for
previously untreated ALL, must be enrolled on this trial

- Acute promyelocytic leukemia (APL)

- Patients enrolled on SWOG-S0521 or SWOG-S0535 for previously untreated APL
must be enrolled on this trial



- Adult

Performance status:

- See Disease Characteristics

Life expectancy:

- See Disease Characteristics


- See Disease Characteristics


- See Disease Characteristics


- See Disease Characteristics


- See Disease Characteristics

Type of Study:


Study Design:

Primary Purpose: Diagnostic

Outcome Measure:

Disease-free survival

Safety Issue:


Principal Investigator

Wendy Stock, MD

Investigator Role:

Study Chair

Investigator Affiliation:

University of Chicago



Study ID:




Start Date:

April 1999

Completion Date:

Related Keywords:

  • Leukemia
  • untreated adult acute lymphoblastic leukemia
  • adult acute promyelocytic leukemia (M3)
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia, Promyelocytic, Acute



Roswell Park Cancer Institute Buffalo, New York  14263
University of Chicago Cancer Research Center Chicago, Illinois  60637
CCOP - Christiana Care Health Services Wilmington, Delaware  19899
CCOP - North Shore University Hospital Manhasset, New York  11030
CCOP - Greenville Greenville, South Carolina  29615
Holden Comprehensive Cancer Center at University of Iowa Iowa City, Iowa  52242-1002
Ellis Fischel Cancer Center at University of Missouri - Columbia Columbia, Missouri  65203
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill Chapel Hill, North Carolina  27599-7570
Naval Medical Center - San Diego San Diego, California  92134-3202
Veterans Affairs Medical Center - Syracuse Syracuse, New York  13210
Queens Cancer Center of Queens Hospital Jamaica, New York  11432
Maine Center for Cancer Medicine and Blood Disorders - Scarborough Scarborough, Maine  04074
Long Island Jewish Medical Center New Hyde Park, New York  11040
Florida Hospital Cancer Institute at Florida Hospital Orlando Orlando, Florida  32803-1273
Mount Sinai Medical Center New York, New York  10029
SUNY Upstate Medical University Hospital Syracuse, New York  13210
Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina  27157-1096
Rhode Island Hospital Comprehensive Cancer Center Providence, Rhode Island  02903
CCOP - Hematology-Oncology Associates of Central New York East Syracuse, New York  13057
Wayne Memorial Hospital, Incorporated Goldsboro, North Carolina  27534
Greenebaum Cancer Center at University of Maryland Medical Center Baltimore, Maryland  21201
New York Weill Cornell Cancer Center at Cornell University New York, New York  10021
UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California  94115
University of Illinois Cancer Center Chicago, Illinois  60612-7243
CancerCare of Maine at Eastern Maine Medical Center Bangor, Maine  04401
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute Boston, Massachusetts  02115
Masonic Cancer Center at University of Minnesota Minneapolis, Minnesota  55455
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis St. Louis, Missouri  63110
CCOP - Nevada Cancer Research Foundation Las Vegas, Nevada  89109-2306
Don Monti Comprehensive Cancer Center at North Shore University Hospital Manhasset, New York  11030
Virginia Commonwealth University Massey Cancer Center Richmond, Virginia  23298-0037
University Medical Center of Southern Nevada Las Vegas, Nevada  89102
Cancer Institute of New Jersey at Cooper - Voorhees Voorhees, New Jersey  08043
Massachusetts General Hospital Boston, Massachusetts  02114-2617
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital Pittsburgh, Pennsylvania  15224-1791
Tunnell Cancer Center at Beebe Medical Center Lewes, Delaware  19958
Monter Cancer Center of the North Shore-LIJ Health System Lake Success, New York  11042
Leo W. Jenkins Cancer Center at ECU Medical School Greenville, North Carolina  27834
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center Columbus, Ohio  43210-1240
Harold Alfond Center for Cancer Care Augusta, Maine  04330
Union Hospital of Cecil County Elkton MD, Maryland  21921
Dana-Farber/Brigham and Women's Cancer Center Boston, Massachusetts  02115
Duke Cancer Institute Durham, North Carolina  27710
Kinston Medical Specialists Kinston, North Carolina  28501
Miriam Hospital Providence, Rhode Island  02906
Greenville Hospital Cancer Center Greenville, South Carolina  29605
Cancer Centers of the Carolinas - Grove Commons Greenville, South Carolina  29605
Cancer Centers of the Carolinas - Faris Road Greenville, South Carolina  29605
Cancer Centers of the Carolinas - Greer Medical Oncology Greer, South Carolina  29650
Cancer Centers of the Carolinas - Seneca Seneca, South Carolina  29672
Cancer Centers of the Carolinas - Spartanburg Spartanburg, South Carolina  29307