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Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus RT for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast


Phase 3
26 Years
N/A
Open (Enrolling)
Female
Breast Cancer

Thank you

Trial Information

Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus RT for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast


OBJECTIVES:

- Compare the efficacy of whole breast radiotherapy vs observation with or without
optional tamoxifen in decreasing or delaying the appearance of local failure (both
invasive and in situ) and preventing the need for mastectomy in women with good-risk
ductal carcinoma in situ (DCIS) of the breast.

- Compare distant disease-free survival of patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to age
(under 50 vs 50 and over), final path margins (negative vs 3-9 mm vs at least 10 mm),
mammographic size of primary (no greater than 1 cm vs greater than 1 cm to 2.5 cm), nuclei
grade (low vs intermediate), and tamoxifen use (yes vs no). Patients are randomized to 1 of
2 treatment arms.

- Arm I: Patients undergo observation and may receive optional oral tamoxifen once daily
(at the discretion of the physician) for 5 years.

- Arm II: Beginning within 12 weeks after final surgery, patients receive radiotherapy to
the whole breast once daily, 5 days a week, for 3.5-5.5 weeks. Patients may receive
optional tamoxifen as in arm I.

Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then
annually thereafter.

PROJECTED ACCRUAL: A total of 1,790 patients will be accrued for this study within 6 years.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Ductal carcinoma in situ (DCIS) of the breast detected by mammogram at the time of
diagnosis

- Unicentric

- Lesions ≤ 2.5 cm

- Low nuclei grade (NG1) or intermediate nuclei grade (NG2) with necrosis in < one
third of the involved ducts

- Inked margins ≥ 3 mm

- Clinically node negative

- Non-palpable

- No suspicious areas on post-operative mammogram taken within 12 weeks after final
surgery

- No bloody nipple discharge

- No more than 12 weeks since prior final surgery (arm II only)

- Hormone receptor status:

- Not specified

PATIENT CHARACTERISTICS:

Age:

- 26 and over

Sex:

- Female

Menopausal status:

- Not specified

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- Not specified

Other:

- Not pregnant or nursing

- No active connective tissue disorders (e.g., lupus or scleroderma)

- No prior malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- No prior chemotherapy

Endocrine therapy:

- No other concurrent hormonal therapy (e.g., raloxifene, hormone replacement therapy,
or birth control pills)

Radiotherapy:

- No prior radiotherapy

Surgery:

- See Disease Characteristics

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Primary Purpose: Treatment

Outcome Measure:

Local recurrence (e.g., invasive or noninvasive recurrence)

Safety Issue:

No

Principal Investigator

Beryl McCormick, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Federal Government

Study ID:

CDR0000067020

NCT ID:

NCT00003857

Start Date:

December 1999

Completion Date:

Related Keywords:

  • Breast Cancer
  • breast cancer in situ
  • ductal breast carcinoma in situ
  • Breast Neoplasms
  • Carcinoma
  • Carcinoma in Situ
  • Carcinoma, Intraductal, Noninfiltrating

Name

Location

Suburban HospitalBethesda, Maryland  20814
Roswell Park Cancer InstituteBuffalo, New York  14263
Memorial Sloan-Kettering Cancer CenterNew York, New York  10021
University of Michigan Comprehensive Cancer CenterAnn Arbor, Michigan  48109-0752
Mayo Clinic - JacksonvilleJacksonville, Florida  32224
Mayo Clinic Cancer CenterRochester, Minnesota  55905
Cardinal Bernardin Cancer Center at Loyola University Medical CenterMaywood, Illinois  60153-5500
Indiana University Cancer CenterIndianapolis, Indiana  46202-5265
Barbara Ann Karmanos Cancer InstituteDetroit, Michigan  48201
University of Mississippi Medical CenterJackson, Mississippi  39216-4505
Duke Comprehensive Cancer CenterDurham, North Carolina  27710
CCOP - Upstate CarolinaSpartanburg, South Carolina  29303
Tripler Army Medical CenterHonolulu, Hawaii  96859-5000
CCOP - Kansas CityKansas City, Missouri  64131
CCOP - Christiana Care Health ServicesWilmington, Delaware  19899
CCOP - North Shore University HospitalManhasset, New York  11030
CCOP - Illinois Oncology Research AssociationPeoria, Illinois  61602
CCOP - Carle Cancer CenterUrbana, Illinois  61801
CCOP - Metro-MinnesotaSaint Louis Park, Minnesota  55416
Veterans Affairs Medical Center - East OrangeEast Orange, New Jersey  07018-1095
Rush-Copley Cancer Care CenterAurora, Illinois  60507
Joliet Oncology-Hematology Associates, Limited - WestJoliet, Illinois  60435
Carle Cancer Center at Carle Foundation HospitalUrbana, Illinois  61801
Saint Anthony Memorial Health CentersMichigan City, Indiana  46360
Cedar Rapids Oncology AssociatesCedar Rapids, Iowa  52403
Baystate Regional Cancer Program at D'Amour Center for Cancer CareSpringfield, Massachusetts  01199
CCOP - Michigan Cancer Research ConsortiumAnn Arbor, Michigan  48106
Genesys Hurley Cancer InstituteFlint, Michigan  48503
Van Elslander Cancer Center at St. John Hospital and Medical CenterGrosse Pointe Woods, Michigan  48236
Foote HospitalJackson, Michigan  49201
Bronson Methodist HospitalKalamazoo, Michigan  49007
West Michigan Cancer CenterKalamazoo, Michigan  49007-3731
Borgess Medical CenterKalamazooaa, Michigan  49001
Seton Cancer Institute - SaginawSaginaw, Michigan  48601
St. John Macomb HospitalWarren, Michigan  48093
Fairview Ridges HospitalBurnsville, Minnesota  55337
Mercy and Unity Cancer Center at Mercy HospitalCoon Rapids, Minnesota  55433
Fairview Southdale HospitalEdina, Minnesota  55435
Mercy and Unity Cancer Center at Unity HospitalFridley, Minnesota  55432
Regions Hospital Cancer Care CenterSt. Paul, Minnesota  55101
United HospitalSt. Paul, Minnesota  55102
Ridgeview Medical CenterWaconia, Minnesota  55387
Mercy Cancer Center at Mercy Medical CenterCanton, Ohio  44708
Case Comprehensive Cancer CenterCleveland, Ohio  44106-5065
St. Rita's Medical CenterLima, Ohio  45801
Natalie Warren Bryant Cancer Center at St. Francis HospitalTulsa, Oklahoma  74136
Geisinger Medical CenterDanville, Pennsylvania  17822-0001
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical CenterWilkes-Barre, Pennsylvania  18711
Medical X-Ray Center, PCSioux Falls, South Dakota  57105
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical CenterLa Crosse, Wisconsin  54601
Massachusetts General Hospital Cancer CenterBoston, Massachusetts  02114
Rapid City Regional HospitalRapid City, South Dakota  57709
Providence Saint Joseph Medical Center - BurbankBurbank, California  91505
CCOP - Bay Area Tumor InstituteOakland, California  94609-3305
CCOP - Santa Rosa Memorial HospitalSanta Rosa, California  95403
Northwest Community HospitalArlington Heights, Illinois  60005
Lutheran General Cancer Care CenterPark Ridge, Illinois  60068
Methodist Medical Center of IllinoisPeoria, Illinois  61636
Memorial Hospital of South BendSouth Bend, Indiana  46601
Cape Cod HospitalHyannis, Massachusetts  02601
CCOP - Montana Cancer ConsortiumBillings, Montana  59101
John F. Kennedy Medical CenterEdison, New Jersey  08818
Newark Beth Israel Medical CenterNewark, New Jersey  07112
CCOP - ColumbusColumbus, Ohio  43206
Reading Hospital and Medical CenterReading, Pennsylvania  19612-6052
Mercy Hospital Cancer Center - ScrantonScranton, Pennsylvania  18501
CCOP - MainLine HealthWynnewood, Pennsylvania  19096
CCOP - GreenvilleGreenville, South Carolina  29615
University of Texas Medical BranchGalveston, Texas  77555-1329
Joe Arrington Cancer Research and Treatment CenterLubbock, Texas  79410-1894
LDS HospitalSalt Lake City, Utah  84143
University of Wisconsin Comprehensive Cancer CenterMadison, Wisconsin  53792
University of Miami Sylvester Comprehensive Cancer CenterMiami, Florida  33136
CCOP - Northern Indiana CR ConsortiumSouth Bend, Indiana  46601
CCOP - Grand RapidsGrand Rapids, Michigan  49503
Ellis Fischel Cancer Center at University of Missouri - ColumbiaColumbia, Missouri  65203
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical CenterLebanon, New Hampshire  03756-0002
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel HillChapel Hill, North Carolina  27599-7570
MetroHealth's Cancer Care Center at MetroHealth Medical CenterCleveland, Ohio  44106
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State UniversityColumbus, Ohio  43210-1240
CCOP - Columbia River Oncology ProgramPortland, Oregon  97225
Kimmel Cancer Center at Thomas Jefferson University - PhiladelphiaPhiladelphia, Pennsylvania  19107
Cancer Research Center of HawaiiHonolulu, Hawaii  96813
North Shore University HospitalManhasset, New York  11030
Cleveland Clinic Taussig Cancer CenterCleveland, Ohio  44195
USC/Norris Comprehensive Cancer Center and HospitalLos Angeles, California  90033-0804
CCOP - Virginia Mason Research CenterSeattle, Washington  98101
Utah Valley Regional Medical Center - ProvoProvo, Utah  84604
Peninsula Regional Medical CenterSalisbury, Maryland  21801
MidMichigan Medical Center - MidlandMidland, Michigan  48670
Monmouth Medical CenterLong Branch, New Jersey  07740-6395
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical CenterMilwaukee, Wisconsin  53201-2901
University of California Davis Cancer CenterSacramento, California  95817
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer InstituteBoston, Massachusetts  02115
University of New Mexico Cancer Research and Treatment CenterAlbuquerque, New Mexico  87131
Fletcher Allen Health Care - University Health Center CampusBurlington, Vermont  05401
Mobile Infirmary Medical CenterMobile, Alabama  36640-0460
St. Vincent Mercy Medical CenterToledo, Ohio  43608
Palmetto Health South Carolina Cancer CenterColumbia, South Carolina  29203
Hillman Cancer Center at University of Pittsburgh Cancer InstitutePittsburgh, Pennsylvania  15236
Great Falls ClinicGreat Falls, Montana  59405
Cancer Research Center at Boston Medical CenterBoston, Massachusetts  02118
Josephine Ford Cancer Center at Henry Ford HospitalDetroit, Michigan  48202
Cancer Institute at Oregon Health and Science UniversityPortland, Oregon  97201-3098
Swedish Cancer Institute at Swedish Medical Center - First Hill CampusSeattle, Washington  98104
Blumenthal Cancer Center at Carolinas Medical CenterCharlotte, North Carolina  28232-2861
McDowell Cancer Center at Akron General Medical CenterAkron, Ohio  44307
Sioux Valley Hospital and University of South Dakota Medical CenterSioux Falls, South Dakota  57117-5134
M.D. Anderson Cancer Center at University of TexasHouston, Texas  77030
Central Baptist HospitalLexington, Kentucky  40503
Trinity Cancer Care CenterMinot, North Dakota  58701
CCOP - Toledo Community HospitalToledo, Ohio  43623-3456
St. Luke's Hospital Cancer CenterBethlehem, Pennsylvania  18015
Mercy Fitzgerald HospitalDarby, Pennsylvania  19023
Waukesha Memorial Hospital Regional Cancer CenterWaukesha, Wisconsin  53188
Long Island Jewish Medical CenterNew Hyde Park, New York  11040
University of Florida Shands Cancer CenterGainesville, Florida  32610-0232
Baptist-South Miami Regional Cancer ProgramMiami, Florida  33176
St. Luke's Mountain States Tumor Institute - BoiseBoise, Idaho  83712-6297
Spectrum Health Cancer Care - Butterworth CampusGrand Rapids, Michigan  49503-2560
Breslin Cancer Center at Ingham Regional Medical CenterLansing, Michigan  48910
Medical University of Ohio Cancer CenterToledo, Ohio  43614
Legacy Emanuel Hospital and Health Center & Children's HospitalPortland, Oregon  97227
Naval Medical Center - PortsmouthPortsmouth, Virginia  23708-2197
St. Vincent Hospital Regional Cancer CenterGreen Bay, Wisconsin  54307-3508
Lahey Clinic Medical Center - BurlingtonBurlington, Massachusetts  01805
St. Mary's - Duluth Clinic Cancer CenterDuluth, Minnesota  55805
Fox Chase-Temple Cancer Center CCOP Research BasePhiladelphia, Pennsylvania  19111-2442
Saint Peter's University HospitalNew Brunswick, New Jersey  08901-1780
Green Bay Oncology, Limited - EscanabaEscanaba, Michigan  49431
CCOP - Hematology-Oncology Associates of Central New YorkEast Syracuse, New York  13057
Mount Nittany Medical CenterState College, Pennsylvania  16803
St. Mary's Hospital Medical Center - Green BayGreen Bay, Wisconsin  54303
Green Bay Oncology, Limited at St. Mary's HospitalGreen Bay, Wisconsin  54303
Bay Area Cancer Care Center at Bay Area Medical CenterMarinette, Wisconsin  54143
Green Bay Oncology, Limited - Oconto FallsOconto Falls, Wisconsin  54154
Green Bay Oncology, Limited - Sturgeon BaySturgeon Bay, Wisconsin  54235
Torrance Memorial Medical CenterTorrance, California  90505
Batte Cancer Center at Northeast Medical CenterConcord, North Carolina  28025
Lacks Cancer Center at Saint Mary's Mercy Medical CenterGrand Rapids, Michigan  49503
Northern Michigan HospitalPetoskey, Michigan  49770
William Beaumont Hospital - Royal Oak CampusRoyal Oak, Michigan  48073
Munson Medical CenterTraverse City, Michigan  49684
Northern Rockies Radiation Oncology CenterBillings, Montana  59101
Deaconess Billings Clinic - DowntownBillings, Montana  59101
Fox Chase Virtua Health Cancer Program - MarltonMarlton, New Jersey  08053
Wayne Memorial Hospital, IncorporatedGoldsboro, North Carolina  27534
Adena Regional Medical CenterChillicothe, Ohio  54601
Riverside Methodist Hospital Cancer CareColumbus, Ohio  43214
Grady Memorial HospitalDelaware, Ohio  43015
Strecker Cancer Center at Marietta Memorial HospitalMarietta, Ohio  45750
Licking Memorial Cancer Care Program at Licking Memorial HospitalNewark, Ohio  43055
Mount Carmel Cancer Services at Mount Carmel St. Ann's HospitalWesterville, Ohio  43081
Cottonwood Hospital Medical CenterMurray, Utah  84107
McKay-Dee Hospital CenterOgden, Utah  84403
Utah Cancer Specialists at UCS Cancer CenterSalt Lake City, Utah  84106
University Cancer Center at University of Washington Medical CenterSeattle, Washington  98195
Group Health Central HospitalSeattle, Washington  98104
Cancer Care Northwest - Spokane SouthSpokane, Washington  99202
Lakeland Cancer Care Center at Lakeland Hospital - St. JosephSaint Joseph, Michigan  49085
Lenoir Memorial Cancer CenterKinston, North Carolina  28503-1678
Zimmer Cancer Center at New Hanover Regional Medical CenterWilmington, North Carolina  28402-9025
Lombardi Comprehensive Cancer Center at Georgetown University Medical CenterWashington, District of Columbia  20007
CCOP - Nevada Cancer Research FoundationLas Vegas, Nevada  89109-2306
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical SchoolNew Brunswick, New Jersey  08903
Madigan Army Medical Center - TacomaTacoma, Washington  98431
Brigham and Women's HospitalBoston, Massachusetts  02115
Leo W. Jenkins Cancer Center at Pitt County Memorial HospitalGreenville, North Carolina  27858-4354
Robert H. Lurie Comprehensive Cancer Center at Northwestern UniversityChicago, Illinois  60611
Paoli Memorial HospitalPaoli, Pennsylvania  19301-1792
Elkhart General HospitalElkhart, Indiana  46515
Maine Medical Center - Bramhall CampusPortland, Maine  04102
Mount Carmel Health - West HospitalColumbus, Ohio  43222
Hillcrest Cancer Center at Hillcrest HospitalMayfield Heights, Ohio  44124
Rosenfeld Cancer Center at Abington Memorial HospitalAbington, Pennsylvania  19001
Lakeland Regional Cancer Center at Lakeland Regional Medical CenterLakeland, Florida  33805
Mount Diablo Regional Cancer CenterConcord, California  94524-4110
North Bay Cancer CenterFairfield, California  94533
Memorial Medical Center Cancer ServicesModesto, California  95355
John Muir/Mt. Diablo Comprehensive Cancer CenterWalnut Creek, California  94598
St. Joseph Medical CenterBloomington, Illinois  61701
InterCommunity Cancer Center of Western IllinoisGalesburg, Illinois  61401
BroMenn Regional Medical CenterNormal, Illinois  61761
Community Cancer CenterNormal, Illinois  61761
Cancer Treatment Center at Pekin HospitalPekin, Illinois  61554
Oncology Hematology Associates of Central Illinois, PC - PeoriaPeoria, Illinois  61615
OSF St. Francis Medical CenterPeoria, Illinois  61637
Valley Cancer CenterSpring Valley, Illinois  61362
Howard Community Hospital at Howard Regional Health SystemKokomo, Indiana  46904
Center for Cancer Therapy at LaPorte Hospital and Health ServicesLa Porte, Indiana  46350
St. Luke's HospitalCedar Rapids, Iowa  52402
Mercy Regional Cancer Center at Mercy Medical CenterCedar Rapids, Iowa  52403
Stormont-Vail Cancer CenterTopeka, Kansas  66604
St. Francis Comprehensive Cancer CenterTopeka, Kansas  66606
Hickman Cancer Center at Bixby Medical CenterAdrian, Michigan  49221
St. Joseph Mercy Cancer Center at St. Joseph Mercy HospitalAnn Arbor, Michigan  48106-0995
Green Bay Oncology, Limited - Iron MountainIron Mountain, Michigan  49801
Upper Michigan Cancer Center at Marquette General HospitalMarquette, Michigan  49855
Virginia Piper Cancer Institute at Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Hubert H. Humphrey Cancer Center at North Memorial Medical CenterRobbinsdale, Minnesota  55422-2900
Coborn Cancer CenterSaint Cloud, Minnesota  56303
CentraCare Clinic - River CampusSt. Cloud, Minnesota  56303
Park Nicollet Health ServicesSt. Louis Park, Minnesota  55416
Booker Cancer Center at Riverview Medical CenterRed Bank, New Jersey  07701
Fox Chase Cancer Center at St. Francis Medical CenterTrenton, New Jersey  08629
Cancer Institute of New Jersey at Cooper - VoorheesVoorhees, New Jersey  08043
Wayne Radiation OncologyGoldsboro, North Carolina  27534
Blanchard Valley Medical AssociatesFindlay, Ohio  45840
Lima Memorial HospitalLima, Ohio  45804
Northwest Ohio Oncology CenterMaumee, Ohio  43537
St. Charles Mercy HospitalOregon, Ohio  43616
Firelands Regional Medical CenterSandusky, Ohio  44870
Mercy Medical CenterSpringfield, Ohio  45504
Promedica Cancer Center at Flower HospitalSylvania, Ohio  43560
Toledo Clinic, Incorporated - Main ClinicToledo, Ohio  43623
Legacy Mount Hood Medical CenterGresham, Oregon  97030
Providence Milwaukie HospitalMilwaukie, Oregon  97222
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer CenterPortland, Oregon  97210
Providence Cancer Center at Providence Portland Medical CenterPortland, Oregon  97213-2967
Providence St. Vincent Medical CenterPortland, Oregon  97225
Legacy Meridian Park HospitalTualatin, Oregon  97062
Bryn Mawr HospitalBryn Mawr, Pennsylvania  19010
St. Mary Regional Cancer CenterLanghorne, Pennsylvania  19047
Lankenau Cancer Center at Lankenau HospitalWynnewood, Pennsylvania  19096
Bon Secours St. Francis Health SystemGreenville, South Carolina  29601
Doctor's Hospital of LaredoLaredo, Texas  78041
Dixie Regional Medical Center - East CampusSaint George, Utah  84770
Southwest Washington Medical Center Cancer CenterVancouver, Washington  98668
Green Bay Oncology, Limited at St. Vincent HospitalGreen Bay, Wisconsin  54301-3526
Fairbanks Cancer Treatment Center at Fairbanks Memorial HospitalFairbanks, Alaska  99701
DeCesaris Cancer Institute at Anne Arundel Medical CenterAnnapolis, Maryland  21401
St. Francis HospitalFederal Way, Washington  98003
Cascade Cancer Center at Evergreen Hospital Medical CenterKirkland, Washington  98034-3013
Providence Holy Cross Cancer CenterMission Hills, California  91346-9600
Northeast Georgia Medical CenterGainesville, Georgia  30501
Good Shepherd HospitalBarrington, Illinois  60010
Creticos Cancer Center at Advocate Illinois Masonic Medical CenterChicago, Illinois  60657
Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins CountyMadisonville, Kentucky  42431
Central Maine Medical CenterLewiston, Maine  04240
Bethke Cancer Center at Emerson HospitalConcord, Massachusetts  01742
Hudner Oncology Center at Saint Anne's HospitalFall River, Massachusetts  02721
Great Lakes Cancer Institute at McLaren Regional Medical CenterFlint, Michigan  48532
West Allis Memorial HospitalWest Allis, Wisconsin  53227
Eastern Connecticut Hematology and Oncology AssociatesNorwich, Connecticut  06360
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/CandlerSavannah, Georgia  31405
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311
Methodist Cancer Center at Methodist Hospital - OmahaOmaha, Nebraska  68114
St. Francis Medical CenterHonolulu, Hawaii  96817
John H. Stroger, Jr. Hospital of Cook CountyChicago, Illinois  60612-9985
Arizona Oncology Services FoundationPhoenix, Arizona  85013
Saint Joseph's Mercy Cancer CenterHot Springs, Arkansas  71913
Enloe Cancer Center at Enloe Medical CenterChico, California  95926
Washington Township HospitalFremont, California  94538
Saint Agnes Medical CenterFresno, California  93720-3397
Cancer Care Consultants Medical Associates at Daniel Freeman Memorial HospitalInglewood, California  90301
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical CenterPomona, California  91767
Radiological Associates of Sacramento Medical Group, IncorporatedSacramento, California  95815
Ruby L. Golleher Cancer Program at Presbyterian Intercommunity HospitalWhittier, California  90602
St. Vincent's Medical CenterBridgeport, Connecticut  06606
Hospital of Saint RaphaelNew Haven, Connecticut  06511
Leeward Radiation Oncology CenterEwa Beach, Hawaii  96706
Queen's Cancer Institute at Queen's Medical CenterHonolulu, Hawaii  96813
Hematology Oncology Associates of Eastern IdahoIdaho Falls, Idaho  83404
Advocate Good Samaritan HospitalDowners Grove, Illinois  60515
St. John's Cancer Center at St. John's Medical CenterAnderson, Indiana  46016
Regional Cancer Institute at Bloomington HospitalBloomington, Indiana  47403
Parkview Regional Cancer Center at Parkview HealthFort Wayne, Indiana  46805
Cancer Treatment Center for Southern KentuckyBowling Green, Kentucky  42101
Greater Baltimore Medical CenterBaltimore, Maryland  21204
MetroWest Medical Center - Framingham Union HospitalFramingham, Massachusetts  01702
Lowell General HospitalLowell, Massachusetts  01854
Community Cancer Care at Milford Regional Medical CenterMilford, Massachusetts  01757
Caritas Norwood HospitalNorwood, Massachusetts  02062
Immanuel St. Joseph's ClinicMankato, Minnesota  56002
Good Samaritan Cancer Center at Good Samaritan HospitalKearney, Nebraska  68848-1990
Dartmouth - Hitchcock ConcordConcord, New Hampshire  03301
Seacoast Cancer Center at Wentworth-Douglass HospitalDover, New Hampshire  03820
Elliot Regional Cancer Center at Elliot HospitalManchester, New Hampshire  03103
Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical CenterEnglewood, New Jersey  07631
AtlantiCare Regional Medical CenterPomona, New Jersey  08240
Albuquerque Regional Medical Center at Lovelace Sandia Health SystemAlbuquerque, New Mexico  87102
Long Island College HospitalBrooklyn, New York  11201
Tucker Center for Cancer Care at Orange Regional Medical CenterMiddletown, New York  10940-4199
Pardee Memorial HospitalHendersonville, North Carolina  28791
Moore Regional Community Hospital Comprehensive Cancer CenterPinehurst, North Carolina  28374
Rex Cancer Center at Rex HospitalRaleigh, North Carolina  27607
Rutherford HospitalRutherfordton, North Carolina  28139
Wilmed Radiation Oncology ServicesWilson, North Carolina  27893
Bethesda North HospitalCincinnati, Ohio  45242
Cancer Treatment Center at Good Samaritan HospitalCincinnati, Ohio  45220
St. Joseph Cancer Center at St. Joseph Health CenterWarren, Ohio  44484
Three Rivers Community HospitalGrants Pass, Oregon  97527
Providence Medford Medical CenterMedford, Oregon  97504
Dubs Cancer Center at Rogue Valley Medical CenterMedford, Oregon  97504
Easton Regional Cancer Center at Easton HospitalEaston, Pennsylvania  18042
Mercy Cancer Institute at Mercy HospitalPittsburgh, Pennsylvania  15219
York Cancer Center at Wellspan HealthYork, Pennsylvania  17403
AnMed Health Cancer CenterAnderson, South Carolina  29621
Gibbs Regional Cancer Center at Spartanburg Regional Medical CenterSpartanburg, South Carolina  29303
Community Cancer Center at Rutland Regional Medical CenterRutland, Vermont  05701
Martha Jefferson Hospital Cancer Care CenterCharlottesville, Virginia  22901
Theda Care Cancer InstituteAppleton, Wisconsin  54911
Community Memorial Hospital Cancer Care CenterMenomonee Falls, Wisconsin  53051
Columbia St. Mary's Cancer Care CenterMilwaukee, Wisconsin  53211
Regional Cancer Center at Oconomowoc Memorial HospitalOconomowoc, Wisconsin  53066