Know Cancer

forgot password

Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus RT for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast

Phase 3
26 Years
Open (Enrolling)
Breast Cancer

Thank you

Trial Information

Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus RT for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast


- Compare the efficacy of whole breast radiotherapy vs observation with or without
optional tamoxifen in decreasing or delaying the appearance of local failure (both
invasive and in situ) and preventing the need for mastectomy in women with good-risk
ductal carcinoma in situ (DCIS) of the breast.

- Compare distant disease-free survival of patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to age
(under 50 vs 50 and over), final path margins (negative vs 3-9 mm vs at least 10 mm),
mammographic size of primary (no greater than 1 cm vs greater than 1 cm to 2.5 cm), nuclei
grade (low vs intermediate), and tamoxifen use (yes vs no). Patients are randomized to 1 of
2 treatment arms.

- Arm I: Patients undergo observation and may receive optional oral tamoxifen once daily
(at the discretion of the physician) for 5 years.

- Arm II: Beginning within 12 weeks after final surgery, patients receive radiotherapy to
the whole breast once daily, 5 days a week, for 3.5-5.5 weeks. Patients may receive
optional tamoxifen as in arm I.

Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then
annually thereafter.

PROJECTED ACCRUAL: A total of 1,790 patients will be accrued for this study within 6 years.

Inclusion Criteria


- Ductal carcinoma in situ (DCIS) of the breast detected by mammogram at the time of

- Unicentric

- Lesions ≤ 2.5 cm

- Low nuclei grade (NG1) or intermediate nuclei grade (NG2) with necrosis in < one
third of the involved ducts

- Inked margins ≥ 3 mm

- Clinically node negative

- Non-palpable

- No suspicious areas on post-operative mammogram taken within 12 weeks after final

- No bloody nipple discharge

- No more than 12 weeks since prior final surgery (arm II only)

- Hormone receptor status:

- Not specified



- 26 and over


- Female

Menopausal status:

- Not specified

Performance status:

- Not specified

Life expectancy:

- Not specified


- Not specified


- Not specified


- Not specified


- Not pregnant or nursing

- No active connective tissue disorders (e.g., lupus or scleroderma)

- No prior malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer or carcinoma in situ of the cervix


Biologic therapy:

- Not specified


- No prior chemotherapy

Endocrine therapy:

- No other concurrent hormonal therapy (e.g., raloxifene, hormone replacement therapy,
or birth control pills)


- No prior radiotherapy


- See Disease Characteristics

Type of Study:


Study Design:

Allocation: Randomized, Primary Purpose: Treatment

Outcome Measure:

Local recurrence (e.g., invasive or noninvasive recurrence)

Safety Issue:


Principal Investigator

Beryl McCormick, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center


United States: Federal Government

Study ID:




Start Date:

December 1999

Completion Date:

Related Keywords:

  • Breast Cancer
  • breast cancer in situ
  • ductal breast carcinoma in situ
  • Breast Neoplasms
  • Carcinoma
  • Carcinoma in Situ
  • Carcinoma, Intraductal, Noninfiltrating



Suburban Hospital Bethesda, Maryland  20814
Roswell Park Cancer Institute Buffalo, New York  14263
Memorial Sloan-Kettering Cancer Center New York, New York  10021
University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan  48109-0752
Mayo Clinic - Jacksonville Jacksonville, Florida  32224
Mayo Clinic Cancer Center Rochester, Minnesota  55905
Cardinal Bernardin Cancer Center at Loyola University Medical Center Maywood, Illinois  60153-5500
Indiana University Cancer Center Indianapolis, Indiana  46202-5265
Barbara Ann Karmanos Cancer Institute Detroit, Michigan  48201
University of Mississippi Medical Center Jackson, Mississippi  39216-4505
Duke Comprehensive Cancer Center Durham, North Carolina  27710
CCOP - Upstate Carolina Spartanburg, South Carolina  29303
Tripler Army Medical Center Honolulu, Hawaii  96859-5000
CCOP - Kansas City Kansas City, Missouri  64131
CCOP - Christiana Care Health Services Wilmington, Delaware  19899
CCOP - North Shore University Hospital Manhasset, New York  11030
CCOP - Illinois Oncology Research Association Peoria, Illinois  61602
CCOP - Carle Cancer Center Urbana, Illinois  61801
CCOP - Metro-Minnesota Saint Louis Park, Minnesota  55416
Veterans Affairs Medical Center - East Orange East Orange, New Jersey  07018-1095
Rush-Copley Cancer Care Center Aurora, Illinois  60507
Joliet Oncology-Hematology Associates, Limited - West Joliet, Illinois  60435
Carle Cancer Center at Carle Foundation Hospital Urbana, Illinois  61801
Saint Anthony Memorial Health Centers Michigan City, Indiana  46360
Cedar Rapids Oncology Associates Cedar Rapids, Iowa  52403
Baystate Regional Cancer Program at D'Amour Center for Cancer Care Springfield, Massachusetts  01199
CCOP - Michigan Cancer Research Consortium Ann Arbor, Michigan  48106
Genesys Hurley Cancer Institute Flint, Michigan  48503
Van Elslander Cancer Center at St. John Hospital and Medical Center Grosse Pointe Woods, Michigan  48236
Foote Hospital Jackson, Michigan  49201
Bronson Methodist Hospital Kalamazoo, Michigan  49007
West Michigan Cancer Center Kalamazoo, Michigan  49007-3731
Borgess Medical Center Kalamazooaa, Michigan  49001
Seton Cancer Institute - Saginaw Saginaw, Michigan  48601
St. John Macomb Hospital Warren, Michigan  48093
Fairview Ridges Hospital Burnsville, Minnesota  55337
Mercy and Unity Cancer Center at Mercy Hospital Coon Rapids, Minnesota  55433
Fairview Southdale Hospital Edina, Minnesota  55435
Mercy and Unity Cancer Center at Unity Hospital Fridley, Minnesota  55432
Regions Hospital Cancer Care Center St. Paul, Minnesota  55101
United Hospital St. Paul, Minnesota  55102
Ridgeview Medical Center Waconia, Minnesota  55387
Mercy Cancer Center at Mercy Medical Center Canton, Ohio  44708
Case Comprehensive Cancer Center Cleveland, Ohio  44106-5065
St. Rita's Medical Center Lima, Ohio  45801
Natalie Warren Bryant Cancer Center at St. Francis Hospital Tulsa, Oklahoma  74136
Geisinger Medical Center Danville, Pennsylvania  17822-0001
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center Wilkes-Barre, Pennsylvania  18711
Medical X-Ray Center, PC Sioux Falls, South Dakota  57105
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center La Crosse, Wisconsin  54601
Massachusetts General Hospital Cancer Center Boston, Massachusetts  02114
Rapid City Regional Hospital Rapid City, South Dakota  57709
Providence Saint Joseph Medical Center - Burbank Burbank, California  91505
CCOP - Bay Area Tumor Institute Oakland, California  94609-3305
CCOP - Santa Rosa Memorial Hospital Santa Rosa, California  95403
Northwest Community Hospital Arlington Heights, Illinois  60005
Lutheran General Cancer Care Center Park Ridge, Illinois  60068
Methodist Medical Center of Illinois Peoria, Illinois  61636
Memorial Hospital of South Bend South Bend, Indiana  46601
Cape Cod Hospital Hyannis, Massachusetts  02601
CCOP - Montana Cancer Consortium Billings, Montana  59101
John F. Kennedy Medical Center Edison, New Jersey  08818
Newark Beth Israel Medical Center Newark, New Jersey  07112
CCOP - Columbus Columbus, Ohio  43206
Reading Hospital and Medical Center Reading, Pennsylvania  19612-6052
Mercy Hospital Cancer Center - Scranton Scranton, Pennsylvania  18501
CCOP - MainLine Health Wynnewood, Pennsylvania  19096
CCOP - Greenville Greenville, South Carolina  29615
University of Texas Medical Branch Galveston, Texas  77555-1329
Joe Arrington Cancer Research and Treatment Center Lubbock, Texas  79410-1894
LDS Hospital Salt Lake City, Utah  84143
University of Wisconsin Comprehensive Cancer Center Madison, Wisconsin  53792
University of Miami Sylvester Comprehensive Cancer Center Miami, Florida  33136
CCOP - Northern Indiana CR Consortium South Bend, Indiana  46601
CCOP - Grand Rapids Grand Rapids, Michigan  49503
Ellis Fischel Cancer Center at University of Missouri - Columbia Columbia, Missouri  65203
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire  03756-0002
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill Chapel Hill, North Carolina  27599-7570
MetroHealth's Cancer Care Center at MetroHealth Medical Center Cleveland, Ohio  44106
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Columbus, Ohio  43210-1240
CCOP - Columbia River Oncology Program Portland, Oregon  97225
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia Philadelphia, Pennsylvania  19107
Cancer Research Center of Hawaii Honolulu, Hawaii  96813
North Shore University Hospital Manhasset, New York  11030
Cleveland Clinic Taussig Cancer Center Cleveland, Ohio  44195
USC/Norris Comprehensive Cancer Center and Hospital Los Angeles, California  90033-0804
CCOP - Virginia Mason Research Center Seattle, Washington  98101
Utah Valley Regional Medical Center - Provo Provo, Utah  84604
Peninsula Regional Medical Center Salisbury, Maryland  21801
MidMichigan Medical Center - Midland Midland, Michigan  48670
Monmouth Medical Center Long Branch, New Jersey  07740-6395
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center Milwaukee, Wisconsin  53201-2901
University of California Davis Cancer Center Sacramento, California  95817
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts  02115
University of New Mexico Cancer Research and Treatment Center Albuquerque, New Mexico  87131
Fletcher Allen Health Care - University Health Center Campus Burlington, Vermont  05401
Mobile Infirmary Medical Center Mobile, Alabama  36640-0460
St. Vincent Mercy Medical Center Toledo, Ohio  43608
Palmetto Health South Carolina Cancer Center Columbia, South Carolina  29203
Hillman Cancer Center at University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania  15236
Great Falls Clinic Great Falls, Montana  59405
Cancer Research Center at Boston Medical Center Boston, Massachusetts  02118
Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan  48202
Cancer Institute at Oregon Health and Science University Portland, Oregon  97201-3098
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Seattle, Washington  98104
Blumenthal Cancer Center at Carolinas Medical Center Charlotte, North Carolina  28232-2861
McDowell Cancer Center at Akron General Medical Center Akron, Ohio  44307
Sioux Valley Hospital and University of South Dakota Medical Center Sioux Falls, South Dakota  57117-5134
M.D. Anderson Cancer Center at University of Texas Houston, Texas  77030
Central Baptist Hospital Lexington, Kentucky  40503
Trinity Cancer Care Center Minot, North Dakota  58701
CCOP - Toledo Community Hospital Toledo, Ohio  43623-3456
St. Luke's Hospital Cancer Center Bethlehem, Pennsylvania  18015
Mercy Fitzgerald Hospital Darby, Pennsylvania  19023
Waukesha Memorial Hospital Regional Cancer Center Waukesha, Wisconsin  53188
Long Island Jewish Medical Center New Hyde Park, New York  11040
University of Florida Shands Cancer Center Gainesville, Florida  32610-0232
Baptist-South Miami Regional Cancer Program Miami, Florida  33176
St. Luke's Mountain States Tumor Institute - Boise Boise, Idaho  83712-6297
Spectrum Health Cancer Care - Butterworth Campus Grand Rapids, Michigan  49503-2560
Breslin Cancer Center at Ingham Regional Medical Center Lansing, Michigan  48910
Medical University of Ohio Cancer Center Toledo, Ohio  43614
Legacy Emanuel Hospital and Health Center & Children's Hospital Portland, Oregon  97227
Naval Medical Center - Portsmouth Portsmouth, Virginia  23708-2197
St. Vincent Hospital Regional Cancer Center Green Bay, Wisconsin  54307-3508
Lahey Clinic Medical Center - Burlington Burlington, Massachusetts  01805
St. Mary's - Duluth Clinic Cancer Center Duluth, Minnesota  55805
Fox Chase-Temple Cancer Center CCOP Research Base Philadelphia, Pennsylvania  19111-2442
Saint Peter's University Hospital New Brunswick, New Jersey  08901-1780
Green Bay Oncology, Limited - Escanaba Escanaba, Michigan  49431
CCOP - Hematology-Oncology Associates of Central New York East Syracuse, New York  13057
Mount Nittany Medical Center State College, Pennsylvania  16803
St. Mary's Hospital Medical Center - Green Bay Green Bay, Wisconsin  54303
Green Bay Oncology, Limited at St. Mary's Hospital Green Bay, Wisconsin  54303
Bay Area Cancer Care Center at Bay Area Medical Center Marinette, Wisconsin  54143
Green Bay Oncology, Limited - Oconto Falls Oconto Falls, Wisconsin  54154
Green Bay Oncology, Limited - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
Torrance Memorial Medical Center Torrance, California  90505
Batte Cancer Center at Northeast Medical Center Concord, North Carolina  28025
Lacks Cancer Center at Saint Mary's Mercy Medical Center Grand Rapids, Michigan  49503
Northern Michigan Hospital Petoskey, Michigan  49770
William Beaumont Hospital - Royal Oak Campus Royal Oak, Michigan  48073
Munson Medical Center Traverse City, Michigan  49684
Northern Rockies Radiation Oncology Center Billings, Montana  59101
Deaconess Billings Clinic - Downtown Billings, Montana  59101
Fox Chase Virtua Health Cancer Program - Marlton Marlton, New Jersey  08053
Wayne Memorial Hospital, Incorporated Goldsboro, North Carolina  27534
Adena Regional Medical Center Chillicothe, Ohio  54601
Riverside Methodist Hospital Cancer Care Columbus, Ohio  43214
Grady Memorial Hospital Delaware, Ohio  43015
Strecker Cancer Center at Marietta Memorial Hospital Marietta, Ohio  45750
Licking Memorial Cancer Care Program at Licking Memorial Hospital Newark, Ohio  43055
Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital Westerville, Ohio  43081
Cottonwood Hospital Medical Center Murray, Utah  84107
McKay-Dee Hospital Center Ogden, Utah  84403
Utah Cancer Specialists at UCS Cancer Center Salt Lake City, Utah  84106
University Cancer Center at University of Washington Medical Center Seattle, Washington  98195
Group Health Central Hospital Seattle, Washington  98104
Cancer Care Northwest - Spokane South Spokane, Washington  99202
Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph Saint Joseph, Michigan  49085
Lenoir Memorial Cancer Center Kinston, North Carolina  28503-1678
Zimmer Cancer Center at New Hanover Regional Medical Center Wilmington, North Carolina  28402-9025
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center Washington, District of Columbia  20007
CCOP - Nevada Cancer Research Foundation Las Vegas, Nevada  89109-2306
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School New Brunswick, New Jersey  08903
Madigan Army Medical Center - Tacoma Tacoma, Washington  98431
Brigham and Women's Hospital Boston, Massachusetts  02115
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital Greenville, North Carolina  27858-4354
Robert H. Lurie Comprehensive Cancer Center at Northwestern University Chicago, Illinois  60611
Paoli Memorial Hospital Paoli, Pennsylvania  19301-1792
Elkhart General Hospital Elkhart, Indiana  46515
Maine Medical Center - Bramhall Campus Portland, Maine  04102
Mount Carmel Health - West Hospital Columbus, Ohio  43222
Hillcrest Cancer Center at Hillcrest Hospital Mayfield Heights, Ohio  44124
Rosenfeld Cancer Center at Abington Memorial Hospital Abington, Pennsylvania  19001
Lakeland Regional Cancer Center at Lakeland Regional Medical Center Lakeland, Florida  33805
Mount Diablo Regional Cancer Center Concord, California  94524-4110
North Bay Cancer Center Fairfield, California  94533
Memorial Medical Center Cancer Services Modesto, California  95355
John Muir/Mt. Diablo Comprehensive Cancer Center Walnut Creek, California  94598
St. Joseph Medical Center Bloomington, Illinois  61701
InterCommunity Cancer Center of Western Illinois Galesburg, Illinois  61401
BroMenn Regional Medical Center Normal, Illinois  61761
Community Cancer Center Normal, Illinois  61761
Cancer Treatment Center at Pekin Hospital Pekin, Illinois  61554
Oncology Hematology Associates of Central Illinois, PC - Peoria Peoria, Illinois  61615
OSF St. Francis Medical Center Peoria, Illinois  61637
Valley Cancer Center Spring Valley, Illinois  61362
Howard Community Hospital at Howard Regional Health System Kokomo, Indiana  46904
Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte, Indiana  46350
St. Luke's Hospital Cedar Rapids, Iowa  52402
Mercy Regional Cancer Center at Mercy Medical Center Cedar Rapids, Iowa  52403
Stormont-Vail Cancer Center Topeka, Kansas  66604
St. Francis Comprehensive Cancer Center Topeka, Kansas  66606
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital Ann Arbor, Michigan  48106-0995
Green Bay Oncology, Limited - Iron Mountain Iron Mountain, Michigan  49801
Upper Michigan Cancer Center at Marquette General Hospital Marquette, Michigan  49855
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Hubert H. Humphrey Cancer Center at North Memorial Medical Center Robbinsdale, Minnesota  55422-2900
Coborn Cancer Center Saint Cloud, Minnesota  56303
CentraCare Clinic - River Campus St. Cloud, Minnesota  56303
Park Nicollet Health Services St. Louis Park, Minnesota  55416
Booker Cancer Center at Riverview Medical Center Red Bank, New Jersey  07701
Fox Chase Cancer Center at St. Francis Medical Center Trenton, New Jersey  08629
Cancer Institute of New Jersey at Cooper - Voorhees Voorhees, New Jersey  08043
Wayne Radiation Oncology Goldsboro, North Carolina  27534
Blanchard Valley Medical Associates Findlay, Ohio  45840
Lima Memorial Hospital Lima, Ohio  45804
Northwest Ohio Oncology Center Maumee, Ohio  43537
St. Charles Mercy Hospital Oregon, Ohio  43616
Firelands Regional Medical Center Sandusky, Ohio  44870
Mercy Medical Center Springfield, Ohio  45504
Promedica Cancer Center at Flower Hospital Sylvania, Ohio  43560
Toledo Clinic, Incorporated - Main Clinic Toledo, Ohio  43623
Legacy Mount Hood Medical Center Gresham, Oregon  97030
Providence Milwaukie Hospital Milwaukie, Oregon  97222
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center Portland, Oregon  97210
Providence Cancer Center at Providence Portland Medical Center Portland, Oregon  97213-2967
Providence St. Vincent Medical Center Portland, Oregon  97225
Legacy Meridian Park Hospital Tualatin, Oregon  97062
Bryn Mawr Hospital Bryn Mawr, Pennsylvania  19010
St. Mary Regional Cancer Center Langhorne, Pennsylvania  19047
Lankenau Cancer Center at Lankenau Hospital Wynnewood, Pennsylvania  19096
Bon Secours St. Francis Health System Greenville, South Carolina  29601
Doctor's Hospital of Laredo Laredo, Texas  78041
Dixie Regional Medical Center - East Campus Saint George, Utah  84770
Southwest Washington Medical Center Cancer Center Vancouver, Washington  98668
Green Bay Oncology, Limited at St. Vincent Hospital Green Bay, Wisconsin  54301-3526
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Fairbanks, Alaska  99701
DeCesaris Cancer Institute at Anne Arundel Medical Center Annapolis, Maryland  21401
St. Francis Hospital Federal Way, Washington  98003
Cascade Cancer Center at Evergreen Hospital Medical Center Kirkland, Washington  98034-3013
Providence Holy Cross Cancer Center Mission Hills, California  91346-9600
Northeast Georgia Medical Center Gainesville, Georgia  30501
Good Shepherd Hospital Barrington, Illinois  60010
Creticos Cancer Center at Advocate Illinois Masonic Medical Center Chicago, Illinois  60657
Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County Madisonville, Kentucky  42431
Central Maine Medical Center Lewiston, Maine  04240
Bethke Cancer Center at Emerson Hospital Concord, Massachusetts  01742
Hudner Oncology Center at Saint Anne's Hospital Fall River, Massachusetts  02721
Great Lakes Cancer Institute at McLaren Regional Medical Center Flint, Michigan  48532
West Allis Memorial Hospital West Allis, Wisconsin  53227
Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut  06360
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler Savannah, Georgia  31405
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center Green Bay, Wisconsin  54311
Methodist Cancer Center at Methodist Hospital - Omaha Omaha, Nebraska  68114
St. Francis Medical Center Honolulu, Hawaii  96817
John H. Stroger, Jr. Hospital of Cook County Chicago, Illinois  60612-9985
Arizona Oncology Services Foundation Phoenix, Arizona  85013
Saint Joseph's Mercy Cancer Center Hot Springs, Arkansas  71913
Enloe Cancer Center at Enloe Medical Center Chico, California  95926
Washington Township Hospital Fremont, California  94538
Saint Agnes Medical Center Fresno, California  93720-3397
Cancer Care Consultants Medical Associates at Daniel Freeman Memorial Hospital Inglewood, California  90301
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center Pomona, California  91767
Radiological Associates of Sacramento Medical Group, Incorporated Sacramento, California  95815
Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital Whittier, California  90602
St. Vincent's Medical Center Bridgeport, Connecticut  06606
Hospital of Saint Raphael New Haven, Connecticut  06511
Leeward Radiation Oncology Center Ewa Beach, Hawaii  96706
Queen's Cancer Institute at Queen's Medical Center Honolulu, Hawaii  96813
Hematology Oncology Associates of Eastern Idaho Idaho Falls, Idaho  83404
Advocate Good Samaritan Hospital Downers Grove, Illinois  60515
St. John's Cancer Center at St. John's Medical Center Anderson, Indiana  46016
Regional Cancer Institute at Bloomington Hospital Bloomington, Indiana  47403
Parkview Regional Cancer Center at Parkview Health Fort Wayne, Indiana  46805
Cancer Treatment Center for Southern Kentucky Bowling Green, Kentucky  42101
Greater Baltimore Medical Center Baltimore, Maryland  21204
MetroWest Medical Center - Framingham Union Hospital Framingham, Massachusetts  01702
Lowell General Hospital Lowell, Massachusetts  01854
Community Cancer Care at Milford Regional Medical Center Milford, Massachusetts  01757
Caritas Norwood Hospital Norwood, Massachusetts  02062
Immanuel St. Joseph's Clinic Mankato, Minnesota  56002
Good Samaritan Cancer Center at Good Samaritan Hospital Kearney, Nebraska  68848-1990
Dartmouth - Hitchcock Concord Concord, New Hampshire  03301
Seacoast Cancer Center at Wentworth-Douglass Hospital Dover, New Hampshire  03820
Elliot Regional Cancer Center at Elliot Hospital Manchester, New Hampshire  03103
Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center Englewood, New Jersey  07631
AtlantiCare Regional Medical Center Pomona, New Jersey  08240
Albuquerque Regional Medical Center at Lovelace Sandia Health System Albuquerque, New Mexico  87102
Long Island College Hospital Brooklyn, New York  11201
Tucker Center for Cancer Care at Orange Regional Medical Center Middletown, New York  10940-4199
Pardee Memorial Hospital Hendersonville, North Carolina  28791
Moore Regional Community Hospital Comprehensive Cancer Center Pinehurst, North Carolina  28374
Rex Cancer Center at Rex Hospital Raleigh, North Carolina  27607
Rutherford Hospital Rutherfordton, North Carolina  28139
Wilmed Radiation Oncology Services Wilson, North Carolina  27893
Bethesda North Hospital Cincinnati, Ohio  45242
Cancer Treatment Center at Good Samaritan Hospital Cincinnati, Ohio  45220
St. Joseph Cancer Center at St. Joseph Health Center Warren, Ohio  44484
Three Rivers Community Hospital Grants Pass, Oregon  97527
Providence Medford Medical Center Medford, Oregon  97504
Dubs Cancer Center at Rogue Valley Medical Center Medford, Oregon  97504
Easton Regional Cancer Center at Easton Hospital Easton, Pennsylvania  18042
Mercy Cancer Institute at Mercy Hospital Pittsburgh, Pennsylvania  15219
York Cancer Center at Wellspan Health York, Pennsylvania  17403
AnMed Health Cancer Center Anderson, South Carolina  29621
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Spartanburg, South Carolina  29303
Community Cancer Center at Rutland Regional Medical Center Rutland, Vermont  05701
Martha Jefferson Hospital Cancer Care Center Charlottesville, Virginia  22901
Theda Care Cancer Institute Appleton, Wisconsin  54911
Community Memorial Hospital Cancer Care Center Menomonee Falls, Wisconsin  53051
Columbia St. Mary's Cancer Care Center Milwaukee, Wisconsin  53211
Regional Cancer Center at Oconomowoc Memorial Hospital Oconomowoc, Wisconsin  53066