The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer
- Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients
with colon cancer.
- Determine if patient prognosis is dependent on the region of 8p AI.
- Perform fine mapping studies to further localize the putative tumor suppressor gene(s)
- Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the
prognosis of patients whose tumors exhibit 8p AI.
OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8
markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136
at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping
PROJECTED ACCRUAL: Approximately 480 patients will be accrued for this study.
Richard M. Goldberg, MD
United States: Federal Government
|St. Mary's/Duluth Clinic Health System||Duluth, Minnesota 55805|