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The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer


N/A
N/A
69 Years
Not Enrolling
Both
Colorectal Cancer

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Trial Information

The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer


OBJECTIVES:

- Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients
with colon cancer.

- Determine if patient prognosis is dependent on the region of 8p AI.

- Perform fine mapping studies to further localize the putative tumor suppressor gene(s)
on 8p.

- Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the
prognosis of patients whose tumors exhibit 8p AI.

OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8
markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136
at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping
studies.

PROJECTED ACCRUAL: Approximately 480 patients will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of resectable stage II or III adenocarcinoma of the colon

- Participated in NCCTG-914653

- DNA extracted from both normal and tumor tissue

PATIENT CHARACTERISTICS:

Age

- Under 70

Performance status

- Not specified

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- Not specified

Endocrine therapy

- Not specified

Radiotherapy

- Not specified

Surgery

- Not specified

Type of Study:

Observational

Study Design:

N/A

Principal Investigator

Richard M. Goldberg, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Mayo Clinic

Authority:

United States: Federal Government

Study ID:

CDR0000066990

NCT ID:

NCT00003833

Start Date:

February 1999

Completion Date:

Related Keywords:

  • Colorectal Cancer
  • stage II colon cancer
  • stage III colon cancer
  • adenocarcinoma of the colon
  • Colonic Neoplasms
  • Colorectal Neoplasms

Name

Location

St. Mary's/Duluth Clinic Health SystemDuluth, Minnesota  55805