Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed unresectable non-small cell lung cancer with a growth
pattern allowing access to the majority of tumor cells via the airway (e.g.,
bronchioloalveolar or papillary adenocarcinoma)

PATIENT CHARACTERISTICS:

Age:

- 18 and over

Performance status:

- ECOG 0-1

Life expectancy:

- At least 12 weeks

Hematopoietic:

- Platelet count greater than 100,000/mm^3

- Prothrombin time and partial thromboplastin time normal

Hepatic:

- Bilirubin less than 1.5 mg/dL

Renal:

- Creatinine less than 1.5 mg/dL

Cardiovascular:

- No New York Heart Association class III or IV heart disease

Pulmonary:

- Room air oxygen saturation greater than 90%

- FEV1 greater than 1.0 L pCO2 less than 50

Other:

- HIV negative

- No active systemic viral, bacterial, or fungal infections requiring treatment

- No concurrent illness requiring hospitalization or intravenous medication

- Not pregnant or nursing

- Effective contraception required of all fertile patients

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- No prior adenovirus gene therapy

- At least 2 weeks since any systemic biologic therapy including prior biologic
response modifiers and recovered

Chemotherapy:

- At least 2 weeks since any prior systemic chemotherapy and recovered

Endocrine therapy:

- Recovered from any prior endocrine therapy

Radiotherapy:

- Recovered from any prior radiotherapy

Surgery:

- At least 2 weeks since any surgical procedure requiring anesthesia

- At least 4 weeks since prior surgical resection of lung tissues

Other:

- No other concurrent therapy