Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically proven stage III or IV renal cancer that has been
completely resected and is at high risk for recurrence, including at least one of the
following: Tumor invades adrenal gland or perinephric tissues but not beyond Gerota's
fascia (T3a) OR Tumor extending into renal vein, vena cava (T3b) OR Tumor grossly extends
into vena cava above diaphragm (T3c) OR Tumor invades beyond Gerota's fascia (T4) OR Any
lymph node involvement totally resected (N1-3) OR Completely resected metastases of all
sites No brain metastases

PATIENT CHARACTERISTICS: Age: Not specified Performance status: ECOG 0-2 Life expectancy:
Not specified Hematopoietic: WBC at least 3,500/mm3 Platelet count at least 100,000/mm3
Hemoglobin at least 9 g/dL Hepatic: Bilirubin less than 3 times upper limit of normal
(ULN) AST or ALT less than 3 times ULN Renal: Creatinine no greater than 1.9 mg/dL
Cardiovascular: No prior myocardial infarction within 6 months No LVEF less than 35% No
primary cardiac arrhythmias beyond occasional PVCs No angina No uncontrolled congestive
heart failure No cerebrovascular accident Pulmonary: No dyspnea at rest or requirement for
supplemental oxygen Oxygen saturation greater than 90% for patients with symptomatic lung
disease Other: Not pregnant or nursing Negative pregnancy test Fetile patients must use
effective contraception Temperatures greater than 100.5 degrees F must have occult
infection excluded No psychiatric disorders

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No concurrent
cyclosporine or methotrexate Endocrine therapy: At least 3 weeks since prior
corticosteroids No concurrent corticosteroids Radiotherapy: Not specified Surgery: At
least 2 weeks since prior surgery Other: At least 3 weeks since prior immunosuppressive
medications No concurrent immunosuppressive medications