A Phase II Trial of Radiosurgery for 1 to 3 Newly Diagnosed Brain Metastases From Renal Cell, Melanoma and Sarcoma
- Evaluate whether the delivery of stereotactic radiosurgery without conventional whole
brain radiotherapy is feasible in patients with 1-3 newly diagnosed brain metastases
from renal cell carcinoma, melanoma, or sarcoma.
- Determine the 3-, 6-, and 12-month radiographic and neurologic intracranial patterns of
progression (i.e., original lesions vs new lesions) in patients treated with this
OUTLINE: This is a multicenter study. Patients are stratified according to maximum tumor
diameter (2 cm vs greater than 2 cm to 3 cm vs greater than 3 cm to 4 cm).
Patients undergo stereotactic radiosurgery at an assigned dose according to tumor diameter.
Patients undergo MRI or CT scan at 3, 6, and 12 months after treatment or until disease
All other therapies are allowed after stereotactic radiosurgery except external beam whole
brain radiotherapy or resection of brain metastases, unless there is documented progression
or unrelenting mass effect that necessitates craniotomy.
Patients are followed every 3 months for 2 years.
PROJECTED ACCRUAL: A total of 36 patients will be accrued for this study within 7.2 months.
Primary Purpose: Treatment
Minesh P. Mehta, MD
University of Wisconsin, Madison
United States: Federal Government
|Ireland Cancer Center||Cleveland, Ohio 44106-5065|
|Milton S. Hershey Medical Center||Hershey, Pennsylvania 17033|
|CCOP - Kalamazoo||Kalamazoo, Michigan 49007-3731|
|Veterans Affairs Medical Center - Madison||Madison, Wisconsin 53705|
|University of Wisconsin Comprehensive Cancer Center||Madison, Wisconsin 53792|
|MBCCOP - University of New Mexico HSC||Albuquerque, New Mexico 87131|
|CCOP - St. Vincent Hospital Cancer Center, Green Bay||Green Bay, Wisconsin 54301|
|Iowa Methodist Medical Center||Des Moines, Iowa 50309|
|Mercy Medical Center||Des Moines, Iowa 50314|
|Iowa Lutheran Hospital||Des Moines, Iowa 50316-2301|
|Alegent Health-Midlands Community Hospital||Papillion, Nebraska 68128-4157|