Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically or cytologically proven advanced metastatic
carcinoma of the breast Bidimensionally measurable disease No brain or leptomeningeal
disease

PATIENT CHARACTERISTICS: Age: Over 18 Performance status: WHO 0-2 Life expectancy: At
least 3 months Hematopoietic: Hemoglobin at least 10 g/dL Neutrophil count at least
2,000/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 11.7
mg/dL AST/ALT no greater than 2 times upper limit of normal (5 times upper limit of normal
in presence of liver metastases) Renal: Creatinine no greater than 1.7 mg/dL
Cardiovascular: No concurrent treatment for congestive cardiac failure Cardiac function
within normal limits by MUGA or ECHO scan, if prior anthracycline therapy Other: Not
pregnant or nursing Fertile patients must use effective contraception No concurrent
nonmalignant systemic disease No active uncontrolled infection No prior history of
malignant disease except: Squamous cell carcinoma of the skin Curatively treated carcinoma
in situ of the cervix

PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent immunological therapy
Chemotherapy: At least 1 prior chemotherapy regimen for advanced disease (including
adjuvant therapy), but not more than 2 prior regimens At least 4 weeks since prior
chemotherapy (6 weeks for nitrosourea or mitomycin) and recovered Cumulative dose of prior
epirubicin no greater than 450 mg/m2 Cumulative dose of prior doxorubicin no greater than
240 mg/m2 No concurrent chemotherapy Endocrine therapy: No concurrent hormonal therapy Low
dose steroid therapy allowed if dose established at least 4 weeks prior to study
Radiotherapy: At least 4 weeks since prior radiotherapy and recovered Surgery: Not
specified Other: No concurrent experimental therapy