Inclusion Criteria

DISEASE CHARACTERISTICS: Patient immunocompromised as the result of any of the following:
Allogeneic bone marrow/peripheral stem cell transplant Autologous bone marrow/peripheral
stem cell transplant Hematological malignancy (including lymphoma) Aplastic anemia and
myelodysplastic syndromes (currently on immunosuppressive treatment) Solid organ
transplantation (other than lung) Other solid organ malignancy (after cytotoxic
chemotherapy) HIV/AIDS High dose prolonged corticosteroid therapy (at least 20 mg/day of
prednisolone or equivalent for more than 3 weeks) or prolonged therapy with other
immunosuppressive agents (e.g., azathioprine, methotrexate) Diagnosis of either definite
or probable acute invasive aspergillosis Fungal infection represents a new episode of
acute invasive aspergillosis Patients with the following are ineligible: Aspergilloma or
allergic bronchopulmonary aspergillosis Chronic invasive aspergillosis Sarcoidosis CMV
pneumonia

PATIENT CHARACTERISTICS: Age: 12 and over Life expectancy: At least 72 hours
Hematopoietic: Not specified Hepatic: Bilirubin no greater than 5 times upper limit of
normal (ULN) SGOT/SGPT no greater than 5 times ULN Alkaline phosphatase no greater than 5
times ULN Renal: Creatinine no greater than 2.5 mg/dL Other: No history of
hypersensitivity or intolerance to azole antifungal agents including miconazole,
ketoconazole, fluconazole, or itraconazole No history of hypersensitivity or severe
intolerance to conventional or lipid formulations of amphotericin B Not pregnant or
nursing Fertile women must use effective contraception Negative pregnancy test No prior
participation on this trial Not on artificial ventilation and unlikely to be extubated
within 24 hours No condition that could affect patient safety, preclude evaluation of
response, or make study completion unlikely

PRIOR CONCURRENT THERAPY: At least 8 weeks since prior systemic treatment with
amphotericin B or itraconazole At least 2 weeks since prior systemic antifungal therapy
for more than 96 hours at doses greater than 0.5 mg/kg/day for conventional or lipid
formulations of amphotericin B or greater than 200 mg/day of itraconazole No concurrent
drugs that are metabolized primarily by hepatic cytochrome P-450 enzymes or which induce
or inhibit these enzymes, such as terfenadine, loratidine, astemizole, midazolam,
triazolam, cisapride, rifampin, rifabutin, barbiturates, carbamazepine, coumarins,
sulfonylureas, nivarapine, erythromycin, ritonavir, delaviridine, omeprazole, and
phenytoin At least 2 weeks since prior rifampin, rifabutin, carbamazepine, or barbiturates
for more than 3 days No concurrent investigational drugs other than cytotoxics,
antiretroviral agents, or therapies for AIDS-related opportunistic infection No concurrent
filgrastim (G-CSF) or sargramostim (GM-CSF) other than for treatment of granulocytopenia
No concurrent white blood cell transfusions No concurrent systemic antifungal agents
active against Aspergillus spp. (e.g., itraconazole, lipid formulations of amphotericin B,
or flucytosine)