Modulation of 5-Fluorouracil With Trimetrexate and Leucovorin in Advanced Pancreatic Cancer
OBJECTIVES: I. Evaluate tumor response to a trimetrexate, fluorouracil and leucovorin
regimen in patients with advanced pancreatic carcinoma. II. Evaluate the toxicities
associated with this regimen in patients with metastatic carcinoma of the pancreas.
OUTLINE: The treatment plan consists of an IV infusion of trimetrexate, followed 24 hours
later by IV infusions of leucovorin and fluorouracil. After another 24 hours oral leucovorin
will be given every 6 hours for 7 doses. A treatment cycle consists of the regimen repeated
weekly for 6 weeks followed by 2 weeks of rest. Treatment cycles will be repeated until
disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: If 3 or more complete or partial responses are observed in the first 22
patients, an additional 11 patients may be accrued for a maximum of 33.
Primary Purpose: Treatment
Agustin Garcia, MD
USC/Norris Comprehensive Cancer Center
United States: Federal Government
|USC/Norris Comprehensive Cancer Center||Los Angeles, California 90033-0800|