VIDEO ASSISTED WEDGE RESECTION (VAR) AND RADIOTHERAPY FOR HIGH RISK T1 NON-SMALL CELL LUNG CANCER: A PHASE II STUDY
- Determine the feasibility of video-assisted thoracoscopic wedge resection (VAR)
followed by radiotherapy in patients with stage I non-small cell lung cancer and
- Determine the incidence of locoregional recurrence in patients treated with this
- Determine the overall and disease-free survival in patients treated with this regimen.
- Determine the technical feasibility of ipsilateral lymph node sampling and complete
resection with VAR in these patients.
- Determine the incidence of conversion to open thoracotomy in these patients.
- Determine the short- and long-term complications associated with VAR in these patients.
- Determine the toxicity of adjuvant radiotherapy after VAR in these patients.
OUTLINE: This is a multicenter study.
Patients undergo video-assisted thoracoscopic wedge resection. Surgeons attempt sampling and
identification of all ipsilateral, mediastinal, and hilar lymph nodes. When accessible,
lobar lymph nodes must also be sampled. If the tumor margins are positive, further resection
of the margins must be attempted. Open thoracotomy may be required for technical reasons.
Eligible patients begin radiotherapy 2-8 weeks postoperatively. Patients with complete
resection undergo radiotherapy 5 days a week for 5.6 weeks. Patients with incomplete
resection undergo radiotherapy 5 days a week for 6.6 weeks.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
PROJECTED ACCRUAL: Approximately 66 patients will be accrued for this study within
approximately 22 months.
Primary Purpose: Treatment
Hani Shennib, MD
Montreal General Hospital
United States: Federal Government
|Beth Israel Deaconess Medical Center||Boston, Massachusetts 02215|
|CCOP - Metro-Minnesota||Saint Louis Park, Minnesota 55416|
|Penn State Cancer Institute at Milton S. Hershey Medical Center||Hershey, Pennsylvania 17033-0850|
|CCOP - MainLine Health||Wynnewood, Pennsylvania 19096|
|MBCCOP - University of New Mexico HSC||Albuquerque, New Mexico 87131|
|CCOP - St. Vincent Hospital Cancer Center, Green Bay||Green Bay, Wisconsin 54301|
|Iowa Lutheran Hospital||Des Moines, Iowa 50316-2301|
|John Stoddard Cancer Center at Iowa Methodist Medical Center||Des Moines, Iowa 50309|
|Mercy Cancer Center at Mercy Medical Center-Des Moines||Des Moines, Iowa 50314|
|Midlands Cancer Center at Midlands Community Hospital||Papillion, Nebraska 68128-4157|
|CCOP - Colorado Cancer Research Program, Incorporated||Denver, Colorado 80224|
|Drexel University Hospital||Philadelphia, Pennsylvania 19102-1192|
|Hillman Cancer Center at University of Pittsburgh Cancer Institute||Pittsburgh, Pennsylvania 15236|