Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed primary ovarian epithelial cancer Stage
III disease, i.e.: Greater than 1 cm residual intraperitoneal disease following
exploratory laparotomy with maximum debulking Laparoscopic resection alone insufficient
The following histologies are eligible: Serous adenocarcinoma Transitional cell carcinoma
Mucinous adenocarcinoma Undifferentiated carcinoma Clear cell adenocarcinoma Mixed
epithelial carcinoma Adenocarcinoma Endometrioid tumor Adenocarcinoma NOS Malignant
Brenner's tumor No unclassified ovarian cancer (i.e., unexplored tumors thought to be of
ovarian origin or tumors not verified as arising from ovarian stroma) No borderline (grade
0) or "probably malignant" carcinoma Measurable disease preferred Patients eligible for
this protocol are also eligible for protocol GOG-136

PATIENT CHARACTERISTICS: Age: Any age Performance status: GOG 0-2 Hematopoietic: WBC at
least 3,000/mm3 Absolute granulocyte count at least 1,500/mm3 Platelet count at least
100,000/mm3 Hepatic: Bilirubin no more than 1.5 times normal ALT, AST, and GGT no more
than 3 times normal Alkaline phosphatase no more than 3 times normal LDH no more than 3
times normal Renal: Creatinine no more than 2.0 mg/dL Cardiovascular: No history of
congestive heart failure No myocardial infarction within 6 months No unstable angina
Other: No septicemia or severe infection No acute hepatitis No severe gastrointestinal
bleeding No second malignancy within 5 years except nonmelanomatous skin cancer Not
pregnant or nursing Effective contraception required of fertile patients

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior cytotoxic
chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery:
See Disease Characteristics No more than 6 weeks since staging surgery