RADIATION WITH MITOMYCIN C OR PORFIROMYCIN IN THE TREATMENT OF CANCER OF THE HEAD AND NECK AREA
OBJECTIVES: I. Compare the efficacy of mitomycin vs. porfiromycin as an adjunct to
radiotherapy for the treatment of epidermoid carcinomas of the head and neck.
OUTLINE: Randomized study. Arm I: Radiotherapy plus Single-Agent Chemotherapy. Irradiation
of involved head and neck sites by external-beam radiotherapy (EBRT) alone (source not
specified), brachytherapy alone (using permanent or removable radiation sources), or both;
plus Mitomycin, MITO, NSC-26980. Arm II: Radiotherapy plus Single-Agent Chemotherapy.
Radiotherapy as in Arm I; plus Porfiromycin, NSC-56410.
PROJECTED ACCRUAL: Approximately 200 patients will be entered over 3-4 years.
Primary Purpose: Treatment
James J. Fischer, MD, PhD
United States: Federal Government
|Yale Comprehensive Cancer Center||New Haven, Connecticut 06520-8028|