Inclusion Criteria

Inclusion Criteria

Concurrent Medication:

Allowed:

- Topical or ophthalmic nucleoside analogs.

Patients must have:

- Confirmation of HIV infection.

- Documented CMV infection.

- No past or present CMV disease (e.g., retinitis, colitis, esophagitis).

- Adequate visualization of the retina of both eyes by ophthalmologist.

- CD4 count <= 50 cells/mm3 (in patients WITHOUT a history of an AIDS-defining
opportunistic infection or chronic gynecologic infection) OR CD4 count <= 100
cells/mm3 (in patients WITH a history of an AIDS-defining opportunistic infection or
chronic gynecologic infection).

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

- Presence of gastrointestinal disease or symptoms not controlled with medications
(e.g., persistent nausea, abdominal pain or persistent diarrhea within the past 4
weeks that is not controllable with medication).

- Inability to comply with protocol.

Concurrent Medication:

Excluded:

- The following nucleoside analogs:

- IV ganciclovir, IV acyclovir for more than 2 weeks total duration, oral acyclovir at
doses > 1000 mg/day, vidarabine, amantadine hydrochloride, cytarabine, idoxuridine.

- FIAU, FIAC, foscarnet, CMV hyperimmune globulin, IV immune globulin, CMV monoclonal
antibody, HPMPC.

- Imipenem-cilastatin (Primaxin).

Patients with the following prior condition are excluded:

History of hypersensitivity to acyclovir.

Prior Medication:

Excluded within the past 60 days:

Ganciclovir, foscarnet, FIAC, FIAU, CMV hyperimmune globulin, CMV monoclonal antibody, or
HPMPC.