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Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. A Pre-Clinical Study of Selective Depletion of Donor Lymphocytes to Prevent Acute Graft-Versus-Host Disease


N/A
18 Years
65 Years
Open (Enrolling)
Both
Graft vs Host Disease, Hematologic Neoplasm

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Trial Information

Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. A Pre-Clinical Study of Selective Depletion of Donor Lymphocytes to Prevent Acute Graft-Versus-Host Disease


This protocol has been written to make available apheresis collections from volunteers
matched to various degrees with recipients in order to test and, if necessary refine, the
selective immunodepletion procedure prior to introducing it in a clinical trial.

Inclusion Criteria


- INCLUSION CRITERIA:

Family members of patients admitted to NHLBI allogeneic BMT protocols.

Ages 18 and older and less than age 65.

Parent of patient (obligate haplotype match) OR HLA 3/6, 4/6, 5/6, or 6/6 match with
patient.

Research apheresis available from patient.

EXCLUSION CRITERIA:

Pregnancy or lactation.

HLA type unknown.

More than one haplotype mismatch with patient.

History of any immunosuppressive disease.

History of chronic viral antigenic stimulus.

Venous access inadequate.

Type of Study:

Observational

Study Design:

Time Perspective: Prospective

Principal Investigator

A. John Barrett, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Heart, Lung, and Blood Institute (NHLBI)

Authority:

United States: Federal Government

Study ID:

990037

NCT ID:

NCT00001872

Start Date:

February 1999

Completion Date:

Related Keywords:

  • Graft Vs Host Disease
  • Hematologic Neoplasm
  • Volunteer
  • Leukocyte Donors
  • Family Members
  • Leukocyte Collection
  • No Reimbursement
  • Neoplasms
  • Graft vs Host Disease
  • Hematologic Neoplasms

Name

Location

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland  20892