Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. A Pre-Clinical Study of Selective Depletion of Donor Lymphocytes to Prevent Acute Graft-Versus-Host Disease
This protocol has been written to make available apheresis collections from volunteers
matched to various degrees with recipients in order to test and, if necessary refine, the
selective immunodepletion procedure prior to introducing it in a clinical trial.
- INCLUSION CRITERIA:
Family members of patients admitted to NHLBI allogeneic BMT protocols.
Ages 18 and older and less than age 65.
Parent of patient (obligate haplotype match) OR HLA 3/6, 4/6, 5/6, or 6/6 match with
Research apheresis available from patient.
Pregnancy or lactation.
HLA type unknown.
More than one haplotype mismatch with patient.
History of any immunosuppressive disease.
History of chronic viral antigenic stimulus.
Venous access inadequate.
Type of Study:
Time Perspective: Prospective
A. John Barrett, M.D.
National Heart, Lung, and Blood Institute (NHLBI)
United States: Federal Government
- Graft Vs Host Disease
- Hematologic Neoplasm
- Leukocyte Donors
- Family Members
- Leukocyte Collection
- No Reimbursement
- Graft vs Host Disease
- Hematologic Neoplasms
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