Inclusion Criteria

Informed consent must be obtained from the patient.

Patients must be female.

Patients must be age 18 or older.

Patients with prevalent and incident cases are eligible.

Patients with the presence or absence of underlying diagnosis or evidence of Tuberous
Sclerosis Complex (TSC) are eligible.

Patients must have a diagnosis of LAM confirmed by any of the following criteria:

Lung biopsy (transbronchial, surgical, transthoracic) judged to be diagnostic by the
Tissue Core pathologists;

OR

Biopsy of lymph node or other mass judged to be diagnostic by the Tissue Core
pathologists;

OR

High resolution CT scan of the chest which is judged to be diagnostic of LAM with a high
degree of certainty by all three of the expert radiologists making up the Imaging Core.

Patients may be enrolled in other protocols.