Trial Information

Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection

Innate immunity plays an important role for fungal recognition and initiation of fungicidal
activity. We hypothesize that subtle differences in different molecules of innate immunity
may contribute to either the predisposition or clinical course of infection with
Cryptococcus neoformans. To test this hypothesis, we propose to analyze the allelic
frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor IIa and IIb,
Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta,
interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1,
chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to
compare this data to the incidence and severity of C neoformans infection. With this study
we hope to identify a group of molecules of innate immunity which influence the risk and
severity of invasive C neoformans infection.