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Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer


N/A
N/A
N/A
Not Enrolling
Both
Breast Neoplasm, Hereditary Neoplastic Syndrome

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Trial Information

Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer


Women who are at high risk for breast cancer, either because of linkage to high risk breast
and ovarian cancer families, or because of a carcinoma in the opposite breast, will be
studied. Women will have a physical examination and mammography to ensure that no breast
abnormalities are present. Eligible women will undergo biopsy of the breast to obtain
normal breast tissue. Short-term cell cultures will be established from this tissue and
early passages of the short-term cell lines will be stored. A bank of high risk normal
mammary epithelial cells will be established. To further characterize the mammary
epithelial cells in this population of women, cell cultures will subsequently be analyzed
for their growth and metabolic properties, sensitivity to chemopreventive agents, steroid
receptor characteristics, oncogene expression and regulation, and genetic changes.

Inclusion Criteria


Women at high risk for breast cancer, either because they are a member of a high risk
breast or ovarian cancer family, or because of a carcinoma of the opposite breast.

Normal mammogram within past 3 months.

No suspicious breast or axillary lesions on physical examination.

No major cardiopulmonary, hepatic or renal disorders.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

960026

NCT ID:

NCT00001496

Start Date:

January 1996

Completion Date:

November 2001

Related Keywords:

  • Breast Neoplasm
  • Hereditary Neoplastic Syndrome
  • BRCA-1
  • Familial Breast Cancer
  • Breast Cell Culture
  • High Risk
  • Breast Neoplasms
  • Neoplasms
  • Neoplastic Syndromes, Hereditary

Name

Location

National Cancer Institute (NCI)Bethesda, Maryland  20892