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Studies of Hyperparathyroidism and Related Disorders


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Open (Enrolling)
Both
Hyperparathyroidism, Hypocalcemia, Hypoparathyroidism, Parathyroid Neoplasm

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Trial Information

Studies of Hyperparathyroidism and Related Disorders


Patients with confirmed or suspected primary hyperparathyroidism or complications therefrom
(such as postoperative hypoparathyroidism) will be admitted for diagnosis and treatment. The
principal diagnostic components are calcium in serum and urine and parathyroid hormone in
serum. Patients with moderately to highly severe primary hyperparathyroidism will be
treated. Treatment will be mainly by parathyroidectomy. Other options are medications or no
intervention. Patients with a hyperparathyroid syndrome may be managed for their
extraparathyroid features. Preoperative testing to localize parathyroid neoplasm(s) will be
used usually and with more extended methods in cases with prior neck surgery. Preoperative
tumor localization tests will be selected according to clinical indications from the
following: ultrasound, technetium-thallium scan, computerized tomography, magnetic resonance
imaging, fine needle aspiration for parathyroid hormone assay, selective arteriogram,
selective venous catheterization for parathyroid hormone assay. Options for management of
postoperative hypocalcemia include calcium, vitamin D analogs, parathyroid autografts and
synthetic parathyroid hormone. Research specimens may consist of blood or tumors.

Inclusion Criteria


- INCLUSION CRITERIA:

Patients (male or female any age) with known or suspected primary hyperparathyroidism or a
related disorder (such as familial multiple endocrine neoplasia type 1 [MEN1]) will be
evaluated.

The vast majority of patients will be greater than age 18.

In the rare occasion where special resources might be appropriate (uremic patient, young
child), the availability of special resources would be confirmed prior to admission.

EXCLUSION CRITERIA:

There are no absolute exclusions.

Type of Study:

Observational

Study Design:

N/A

Principal Investigator

Stephen J Marx, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Authority:

United States: Federal Government

Study ID:

910085

NCT ID:

NCT00001277

Start Date:

March 1991

Completion Date:

Related Keywords:

  • Hyperparathyroidism
  • Hypocalcemia
  • Hypoparathyroidism
  • Parathyroid Neoplasm
  • Parathyroid
  • Calcium
  • Vitamin D
  • Neoplasms
  • Hyperparathyroidism
  • Hypocalcemia
  • Hypoparathyroidism
  • Parathyroid Neoplasms

Name

Location

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland  20892
United Services University of Health ServicesBethesda, Maryland  20889