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Evaluation of Biological, Immunological and Therapeutic Parameters in Brain Tumor Patients

Not Enrolling
Brain Neoplasm, Glioblastoma, Glioma, Pituitary Neoplasm

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Trial Information

Evaluation of Biological, Immunological and Therapeutic Parameters in Brain Tumor Patients

This protocol involves the study of human brain tumor cells outside the body in the
laboratory as part of an attempt to better understand these tumors and to develop more
effective therapeutic measures.

Malignant primary brain tumor patients at present have a life expectancy of approximately 15
weeks following surgery unless other adjunctive measures are taken. With currently
available adjunctive therapy the life expectancy reaches 50 weeks.

These survival data have spurred extensive efforts to develop new treatment modalities.
Radiation, chemotherapy and immunotherapy have been mildly helpful adjuncts but their use
has been largely on empirical grounds or on the basis of experimentation on animal tumor
models often quite different in nature from human brain tumors.

Our group has sought to develop data upon which to devise new treatment strategies for
patients with malignant brain tumors.

The foundation of our approach rests upon the use of in vitro studies of the cell biology of
each patient's tumor.

It is our plan to utilize these tumors for in vitro investigation of the immunology,
biology, biochemistry and molecular biology of brain tumors. Optimal conventional therapy
will be given to the patients as we seek to learn more of how the scientific information
obtained can be used to help them.

Inclusion Criteria


Patients to be studied will have either undergone surgical confirmation of a malignant
primary brain tumor or be considered likely to have that diagnosis on the basis of
diagnostic studies.

They should have survival likelihood of at least three months and be able to comprehend
the nature of the proposed program.

Type of Study:


Study Design:



United States: Federal Government

Study ID:




Start Date:

July 1979

Completion Date:

September 2005

Related Keywords:

  • Brain Neoplasm
  • Glioblastoma
  • Glioma
  • Pituitary Neoplasm
  • Brain Tumors
  • Glioma
  • Glioblastoma Multiforme
  • Pituitary Adenoma
  • Brain Neoplasms
  • Neoplasms
  • Glioblastoma
  • Glioma
  • Pituitary Neoplasms



National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland  20892