Blood Sampling for Neurochemical and Genetic Testing
This project is to allow blood sampling from normal volunteers and patients with
dysautonomia, pheochromocytoma, hypertension, or neurogenetic diseases involving
catecholaminergic systems. The blood is used to establish normal values for plasma levels
of catechols and related neurochemicals; test for abnormal neurochemical patterns in
patients; and establish a "bank" of DNA samples from normal volunteers and from patients, to
be used in future studies about mutations or polymorphisms of catecholamine-related genes.
The subjects are healthy normal volunteers or patients with dysautonomia,
pheochromocytoma, hypertension, or neurogenetic diseases involving catecholaminergic
systems. Children of any age above 4 years may participate. In the case of minors,
consent is obtained from an adult who is legally responsible for the subject.
Subjects in whom anatomic or technical factors preclude insertion of an arm intravenous
(i.v.) catheter are excluded. Normal volunteers taking any prescribed medication are
excluded. Normal volunteers who smoke cigarettes or consume alcohol daily are excluded.
Type of Study:
United States: Federal Government
- Autonomic Nervous System Disease
- Tyrosine Hydroxylase
- Monoamine Oxidase
- Sympathetic Nervous System
- Autonomic Nervous System Diseases
- Primary Dysautonomias
- Nervous System Diseases
|National Institute of Neurological Disorders and Stroke (NINDS)||Bethesda, Maryland 20892|