Inclusion Criteria

Inclusion Criteria

Concurrent Medication:

Allowed:

- PCP prophylaxis (required for patients with CD4 count < 200 cells/mm3).

- Chemoprophylaxis for candidiasis and herpes simplex.

- Metronidazole for up to 14 days.

- Erythropoietin.

Patients must have:

- HIV seropositivity.

- NO active opportunistic infection requiring treatment with prohibited drugs.

- Phase I - Current grade 1 AIN (i.e., low grade SIL) OR treated or untreated grade 2
or 3 AIN (i.e., high grade SIL).

Phase II - Prior histologically confirmed grade 2 or 3 AIN / high grade SIL, with ablative
therapy within the past 30-90 days.

- Capability of complying with study protocol.

NOTE:

- The terms condyloma, grade 1 AIN, and low grade SIL are interchangeable. Grade 2 or 3
AIN is interchangeable with high grade SIL.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

- Active medical problems for which the patient is undergoing evaluations or for which
prohibited therapy is required.

- Other active malignancies requiring systemic therapy.

- Significant symptomatic cardiac disease.

NOTE:

- Patients with malignancies being managed with local therapy (e.g., Kaposi's sarcoma,
basal cell carcinoma) may enroll at the discretion of the site investigator.

Concurrent Medication:

Excluded:

- G-CSF (filgrastim).

- Myelosuppressive antibiotics (except co-trimoxazole for PCP prophylaxis).

- Corticosteroids.

- Biologic response modifiers.

- Cytotoxic chemotherapy.

Concurrent Treatment:

Excluded:

- Radiation therapy.

Patients with the following prior conditions are excluded:

History of ventricular arrhythmias or myocardial infarction.

Prior Medication:

Excluded within 20 days prior to study entry:

- G-CSF (filgrastim).

- Myelosuppressive antibiotics (except co-trimoxazole for PCP prophylaxis).

- Corticosteroids.

- Biologic response modifiers.

- Cytotoxic chemotherapy.

Prior Treatment:

Excluded within 20 days prior to study entry:

- Radiation therapy.

Excluded within 14 days prior to study entry:

- Transfusion.

Active substance abuse or illegal drug use (alcohol consumption is strongly discouraged).