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Safety and Efficacy of Zidovudine for Asymptomatic HIV-Infected Individuals

Phase 3
18 Years
Not Enrolling
HIV Infections

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Trial Information

Safety and Efficacy of Zidovudine for Asymptomatic HIV-Infected Individuals

Results from several studies show that a high percentage of people infected with HIV will
eventually develop AIDS or ARC unless an effective treatment is found. Because AZT is known
to prolong survival in patients with AIDS or severe ARC and has acceptable toxicity in
advanced disease, it is reasonable to try it in less advanced cases.

Patients entered in the study are randomly assigned to one of two doses of AZT or to placebo
(inactive medication). Patients take 3 capsules 5 times a day (every 4 hours from 8 am until
12 pm).

The capsules contain either AZT or placebo and are identical in appearance so that neither
patient nor physician knows which treatment the patient is receiving. The higher dose
corresponds to the dose found to be useful in patients with AIDS or severe ARC. Patients
visit the clinic every 2 weeks for the first 16 weeks, then once a month after that for
evaluation. Treatment will continue until the results from the study have been analyzed,
which could be as long as 3 years. If side effects occur, the dose of study medication will
be decreased or temporarily stopped. If the side effects are severe, then study medication
will be stopped permanently.

AMENDED: Effective with Version 4 (900226), dosing for ALL patients on Phase 2 study drug,
regardless of CD4+ substudy, will proceed as open-label AZT. Original treatment assignments
employed in the > 500 cells/mm3 substudy during the period from August 16, 1989 through the
release of this new version. Also, toxicity management and dose modification of AZT for
patients receiving Phase 2 study drug have been changed.

Inclusion Criteria

Inclusion Criteria

Patients must:

- Be HIV seropositive and asymptomatic.

- Have normal neurologic exam as defined by the Micro Neuro-AIDS assessment.

Concurrent Medication

- Required: Prophylaxis for Pneumocystis carinii pneumonia (PCP). Aerosolized
pentamidine is preferred but if not possible, Trimethoprim / sulfamethoxazole 1 DS
tablet per day or Dapsone 50 - 100 mg per day is allowed.

Exclusion Criteria

- Active drug or alcohol abuse sufficient to prevent adequate compliance with study
therapy in the investigator's opinion.

Co-existing Condition:

Patients with the following diseases or conditions are excluded:

- Hemophilia.

- Oral candida infection documented by morphology or by response to antifungal therapy
within 2 years of study entry.

- Oral hairy leukoplakia at any time prior to study entry.

- Herpes zoster infection (including single dermatome infection) within 2 years of
study entry.

- Active diarrhea as defined by 3 or more liquid stools per day.

- Temperature > 37.8 degrees C.

- Grade 1 impairment on two or more items (mild AIDS dementia complex) in the ACTG
Micro Neuro-AIDS Assessment.

- Prior history of malignancy other than cutaneous basal cell carcinomas or cervical
carcinoma in situ.

Patients with the following are excluded from entry:

- AIDS or AIDS-related complex defining symptoms.

- Significant, chronic underlying medical illnesses which would impair continuous
participation in this 3-year clinical trial.

- Hemophilia.

Prior Medication: Excluded:

- Chemoprophylaxis for Pneumocystis carinii pneumonia (PCP).

- Other experimental medications.

- Excluded within 60 days of study entry:

- Antiretroviral drugs or immunomodulators (biologic response modifiers).

- Excluded within 120 days of study entry:

- Systemic corticosteroids.

Prior Treatment: Excluded within 3 months of study entry:

- Blood transfusion.

Type of Study:


Study Design:

Masking: Double-Blind, Primary Purpose: Treatment

Principal Investigator

Volberding P

Investigator Role:

Study Chair


United States: Federal Government

Study ID:

ACTG 019



Start Date:

Completion Date:

February 1995

Related Keywords:

  • HIV Infections
  • Acquired Immunodeficiency Syndrome
  • AIDS-Related Complex
  • Zidovudine
  • HIV Infections
  • Acquired Immunodeficiency Syndrome



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