Inclusion Criteria

Inclusion Criteria

Concurrent Treatment:

Allowed:

- Local radiotherapy or laser therapy to cosmetically apparent Kaposi's lesions,
provided the dose to any one lesion does not exceed 3000 gray and the total surface
area of all lesions treated does not exceed 10 cm2 during the course of the trial.

Patients must demonstrate the following clinical and laboratory findings:

- Positive for HIV by federally licensed ELISA test.

- Acceptable bone marrow function.

- Acceptable renal function.

- Acceptable hepatic function.

Exclusion Criteria

Concurrent Medication:

Excluded:

- Other potentially antiretroviral compounds.

Patients will be excluded from the study for the following reasons:

- Concurrent, active opportunistic infections requiring therapy.

- Extensive Kaposi's sarcoma with more than 100 cutaneous lesions, requiring systemic
chemotherapy, prior treatment with more than one chemotherapy regimen, excluding
intralesional therapy, or symptomatic visceral Kaposi's sarcoma.

- Evidence of clinically significant cardiac dysfunction (New York Heart Association
grade III or IV).

- History of malignant neoplasms other than nonmelanomatous skin cancer or cancer in
situ of the cervix.

- Proteinuria of 2+ or greater and/or 24-hour urine protein of greater than 1.

Prior Medication:

Excluded:

- More than one chemotherapy regimen for Kaposi's sarcoma.

- Any interferon preparation or zidovudine (AZT).

- Excluded within 30 days of study entry:

- Other immunomodifiers.

- Acyclovir.

- Other investigational drugs.

- Excluded within 60 days of study entry:

- Cytotoxic therapy.

Patients may not have any of the following diseases or symptoms:

- Development of an AIDS-defining opportunistic infection, other than oral thrush or
localized zoster.

- Non-Kaposi's sarcoma, AIDS-defining malignancy.